Detail publikačního výsledku

Correlated Mutation Analysis Improvement by Proteomic Signal Processing

KUPKOVÁ, K.; SEDLÁŘ, K.; PROVAZNÍK, I.

Originální název

Correlated Mutation Analysis Improvement by Proteomic Signal Processing

Anglický název

Correlated Mutation Analysis Improvement by Proteomic Signal Processing

Druh

Stať ve sborníku v databázi WoS či Scopus

Originální abstrakt

Correlated mutation analysis has become a powerful tool in protein contact prediction based on multiple sequence alignments of homologous proteins. Here, we introduce a novel method for the computation of correlated mutations based on prior transformation of protein sequences into their numerical form, which provides important biological properties about the amino acids. The method is then incorporated into a compact technique replacing the previously proposed Jaccard index. This results in the significant improvement of all of the statistical parameters used in this study.

Anglický abstrakt

Correlated mutation analysis has become a powerful tool in protein contact prediction based on multiple sequence alignments of homologous proteins. Here, we introduce a novel method for the computation of correlated mutations based on prior transformation of protein sequences into their numerical form, which provides important biological properties about the amino acids. The method is then incorporated into a compact technique replacing the previously proposed Jaccard index. This results in the significant improvement of all of the statistical parameters used in this study.

Klíčová slova

correlated mutations; protein contact map; numerical representation

Klíčová slova v angličtině

correlated mutations; protein contact map; numerical representation

Autoři

KUPKOVÁ, K.; SEDLÁŘ, K.; PROVAZNÍK, I.

Rok RIV

2017

Vydáno

29.08.2016

Místo

Brno

ISBN

978-80-214-5389-0

Kniha

Sborník příspěvků studentské konference Blansko 2016

Strany od

47

Strany do

50

Strany počet

105

URL

http://www.radio.feec.vutbr.cz/ieee/userfiles/downloads/archive/2016-Blansko/Sbornik_Blansko_2016.pdf

BibTex

@inproceedings{BUT127645,
  author="Kristýna {Kupková} and Karel {Sedlář} and Valentýna {Provazník}",
  title="Correlated Mutation Analysis Improvement by
Proteomic Signal Processing",
  booktitle="Sborník příspěvků studentské konference Blansko 2016",
  year="2016",
  number="1",
  pages="47--50",
  address="Brno",
  isbn="978-80-214-5389-0",
  url="http://www.radio.feec.vutbr.cz/ieee/userfiles/downloads/archive/2016-Blansko/Sbornik_Blansko_2016.pdf"
}