Detail publikačního výsledku

Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi

KOŠČOVÁ, P.

Originální název

Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi

Anglický název

Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi

Druh

Stať ve sborníku mimo WoS a Scopus

Originální abstrakt

The number of drug-resistant strains of Borrelia burgdorferi necessitated the identification of potential drug targets specific to the strain of interest. The chromosomal and plasmid genes of B. burgdorferistrain B31 were compared with erythromycin-resistant B. burgdorferistrain N40 to find common (core) and unique (strain-specific) genes in present study. In silicoanalysis of genomic data showed total number of unique genes higher in strain N40. The presence of higher number of unique genes in N40 signifies their role in drug resistance mechanism. Furthermore, human proteome was compared with proteome of these strains to find target protein specific to the strain of interest and not present in host. In conclusion, identification of unique genes in these strains provided on differences in drug resistance potential.

Anglický abstrakt

The number of drug-resistant strains of Borrelia burgdorferi necessitated the identification of potential drug targets specific to the strain of interest. The chromosomal and plasmid genes of B. burgdorferistrain B31 were compared with erythromycin-resistant B. burgdorferistrain N40 to find common (core) and unique (strain-specific) genes in present study. In silicoanalysis of genomic data showed total number of unique genes higher in strain N40. The presence of higher number of unique genes in N40 signifies their role in drug resistance mechanism. Furthermore, human proteome was compared with proteome of these strains to find target protein specific to the strain of interest and not present in host. In conclusion, identification of unique genes in these strains provided on differences in drug resistance potential.

Klíčová slova

Borrelia burgdorferi; Lyme disease; erythromycin; resistance

Klíčová slova v angličtině

Borrelia burgdorferi; Lyme disease; erythromycin; resistance

Autoři

KOŠČOVÁ, P.

Rok RIV

2017

Vydáno

28.04.2016

Nakladatel

Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií

ISBN

978-80-214-5350-0

Kniha

Proceedings of the 22nd Conference STUDENT EEICT 2016

Strany od

523

Strany do

527

Strany počet

5

BibTex

@inproceedings{BUT124355,
  author="Pavlína {Cicková}",
  title="Comparative Analysis of Common and Unique Targets in Drug Resistant Strains of Borrelia burgdorferi",
  booktitle="Proceedings of the 22nd Conference STUDENT EEICT 2016",
  year="2016",
  number="1",
  pages="523--527",
  publisher="Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií",
  isbn="978-80-214-5350-0"
}