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Detail publikačního výsledku
EL-SHAMY, I.; BAKEER, H.; AL-SHAMRANI, K.; ABDEL-LATTIF, A.; AL-SHEHRI, M.
Originální název
Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one
Anglický název
Druh
Článek Scopus
Originální abstrakt
A series of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (3) and 2-((1-substituted- 1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (4) were synthesized starting from 4-arylphthalazin- 1(2H)-one (1). Moreover, the N-glycosyl of 2-((1H-benzo[d]imidazol-2-yl)methyl)-4-arylphthalazin-1(2H)-one (5a,b) were synthesized by interaction of phthalazinone derivative (3) with acetobromo-alfa-D-glucose. Deacetylation of acetylated N-nucleosides 5a,b using ammonia solution in methanol afforded the corresponding deacetylatedNglycosyl 6a,b respectively. The structures of the synthesized compounds were confirmed by 1HNMR, 13CNMR, MS, IR spectroscopy and by elemental analysis.
Anglický abstrakt
Klíčová slova
N-glycosyl; phthalazinone; antimicrobial activity, Benzamidazole
Klíčová slova v angličtině
Autoři
Rok RIV
2015
Vydáno
01.04.2014
ISSN
1097-8135
Periodikum
Life Science Journal
Svazek
11
Číslo
4
Stát
Čínská lidová republika
Strany od
94
Strany do
99
Strany počet
6
BibTex
@article{BUT112296, author="Ibrahim E. {El-Shamy} and Hadeer M. {Bakeer} and Khalid M. {Al-Shamrani} and Abdelmohsen Moustafa {Abdellatif} and Mohammed M. {Al-Shehri}", title="Synthesis of some new N-glycosyl and 4-aryl-2-((1-(piperidin-1-ylmethyl)-1H-benzo[d] imidazol-2- yl)methyl)phthalazin-1(2H)-one", journal="Life Science Journal", year="2014", volume="11", number="4", pages="94--99", issn="1097-8135" }