Detail publikačního výsledku

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

SOCHOR, J.; NEJDL, L.; RUTTKAY-NEDECKÝ, B.; BEZDĚKOVÁ, A.; LUKEŠOVÁ, K.; ZÍTKA, O.; CERNEI, N.; MAREŠ, P.; POHANKA, M.; ADAM, V.; BABULA, P.; BEKLOVÁ, M.; ZEMAN, L.; KIZEK, R.

Originální název

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Anglický název

Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach

Druh

Článek WoS

Originální abstrakt

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation. (C) 2013 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Anglický abstrakt

Taurine (2-aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues. It is involved in many physiological processes. Thus, it is widely discussed especially due to its antioxidant properties. In this study, we focused on the effect of taurine supplementation on the concentration of antioxidants in blood plasma and erythrocytes of Wistar rats. Taurine was applied in feed mixture in the dosage of 0, 1, 250, 500, 750, 1000, 1500, 2000, 2500, 3000, 3500 and 4000 mg/kg. We monitored both enzymatic and non-enzymatic antioxidants - glutathione peroxidase, glutathione reductase, and superoxide dismutase and reduced/oxidized glutathione and metallothionein. Using three different methods 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), Ferric Reducing Antioxidant Power (FRAP) and free radicals, we determined antioxidant capacity. In addition, we monitored levels of uric acid and glucose. Our results revealed significant changes in both enzymatic and non-enzymatic parameters with the increasing taurine supplementation. (C) 2013 Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Klíčová slova

Taurine; Thiol antioxidant; Oxidative stress; Glutathione; Metallothionein; Wistar rats

Klíčová slova v angličtině

Taurine; Thiol antioxidant; Oxidative stress; Glutathione; Metallothionein; Wistar rats

Autoři

SOCHOR, J.; NEJDL, L.; RUTTKAY-NEDECKÝ, B.; BEZDĚKOVÁ, A.; LUKEŠOVÁ, K.; ZÍTKA, O.; CERNEI, N.; MAREŠ, P.; POHANKA, M.; ADAM, V.; BABULA, P.; BEKLOVÁ, M.; ZEMAN, L.; KIZEK, R.

Rok RIV

2015

Vydáno

01.04.2014

Nakladatel

UNIV SOUTH BOHEMIA, FAC HEALTH & SOCIAL STUD, JIROVCOVA, CESKA BUDEJOVICE, 370 04, CZECH REPUBLIC

Místo

CESKA BUDEJOVICE, 370 04, CZECH REPUBLIC

ISSN

1214-021X

Periodikum

Journal of Applied Biomedicine

Svazek

12

Číslo

2

Stát

Česká republika

Strany od

97

Strany do

110

Strany počet

14

URL

http://www.sciencedirect.com/science/article/pii/S1214021X13000094

BibTex

@article{BUT112150,
  author="Jiří {Sochor} and Lukáš {Nejdl} and Branislav {Ruttkay-Nedecký} and Andrea {Bezděková} and Kateřina {Lukešová} and Ondřej {Zítka} and Natalia Vladimirovna {Cernei} and Petr {Mareš} and Miroslav {Pohanka} and Vojtěch {Adam} and Petr {Babula} and Miroslava {Beklová} and Ladislav {Zeman} and René {Kizek}",
  title="Investigating the influence of taurine on thiol antioxidant status in Wistar rats with a multi-analytical approach",
  journal="Journal of Applied Biomedicine",
  year="2014",
  volume="12",
  number="2",
  pages="97--110",
  doi="10.1016/j.jab.2013.01.002",
  issn="1214-021X",
  url="http://www.sciencedirect.com/science/article/pii/S1214021X13000094"
}