Detail publikačního výsledku

MALDI-TOF MS as evolving cancer diagnostic tool: A review

MERLOS RODRIGO, M.; ZÍTKA, O.; KŘÍŽKOVÁ, S.; MOULICK, A.; ADAM, V.; KIZEK, R.

Originální název

MALDI-TOF MS as evolving cancer diagnostic tool: A review

Anglický název

MALDI-TOF MS as evolving cancer diagnostic tool: A review

Druh

Článek WoS

Originální abstrakt

Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013

Anglický abstrakt

Recent developments in mass spectrometry have introduced clinical proteomics to the forefront of diseases diagnosis, offering reliable, robust and efficient analytical method for biomarker discovery and monitoring. MALDI-TOF is a powerful tool for surveying proteins and peptides comprising the realm for clinical analysis. MALDI-TOF has the potential to revolutionize cancer diagnostics by facilitating biomarker discovery, enabling tissue imaging and quantifying biomarker levels. Healthy (control) and cancerous tissues can be analyzed on the basis of mass spectrometry (MALDI-TOF) imaging to identify cancer-specific changes that may prove to be clinically useful. We review MALDI-TOF profiling techniques as tools for detection of cancer biomarkers in various cancers. We mainly discuss recent advances including period from 2011 to 2013

Klíčová slova

Mass spectrometry, Imaging, Tissue profiling, Cancer biomarkers, MALDI-TOF

Klíčová slova v angličtině

Mass spectrometry, Imaging, Tissue profiling, Cancer biomarkers, MALDI-TOF

Autoři

MERLOS RODRIGO, M.; ZÍTKA, O.; KŘÍŽKOVÁ, S.; MOULICK, A.; ADAM, V.; KIZEK, R.

Vydáno

01.07.2014

ISSN

0731-7085

Periodikum

Journal of Pharmaceutical and Biomedical Analysis

Svazek

95

Číslo

1

Stát

Nizozemsko

Strany od

245

Strany do

255

Strany počet

11

BibTex

@article{BUT111182,
  author="Miguel Ángel {Merlos Rodrigo} and Ondřej {Zítka} and Soňa {Křížková} and Amitava {Moulick} and Vojtěch {Adam} and René {Kizek}",
  title="MALDI-TOF MS as evolving cancer diagnostic tool: A review",
  journal="Journal of Pharmaceutical and Biomedical Analysis",
  year="2014",
  volume="95",
  number="1",
  pages="245--255",
  doi="10.1016/j.jpba.2014.03.007",
  issn="0731-7085"
}