Infections associated with Ti implants pose significant risks and economic burdens. Current coatings often lack strong adhesion and durability, particularly against superbugs. The NIR-CURATOR project addresses this challenge by developing an intelligent, cost-effective, and long-lasting multi-layer coating for Ti5Cu5Nb alloy. Combining polydopamine (PDA), hydroxyapatite (HA), and metal phenolic networks (MPNs), this novel coating provides dual antibacterial activity and enhances osteogenesis and mechanical durability. The Ti5Cu5Nb scaffolds exhibit intrinsic and extrinsic antibacterial properties, offering a robust defence against biofilm formation. PDA improves interfacial bonding, while HA promotes osteoconductivity. The MPN outer layer disrupts bacterial membranes, and catalyses oxidative stress pathways. Cu and Ga ions further inhibit bacterial growth and trigger anti-inflammatory responses, with NIR irradiation enhancing antibacterial effects. Computational studies using density functional theory and molecular dynamics will elucidate the coating's antibacterial mechanisms.

Klíčová slova
Additive manufacturing;; Direct ink writing;;; Titanium; Metal networks;; Coatings; Bone repair;; Photothermal; Nanomaterials; Antimicrobial resistance;; Computational chemistry;; Molecular dynamics;; Density functional theory;;; Antibacterial

26-19991L

angličtina

Montufar Jiménez Edgar Benjamin, M.Sc., Ph.D. - hlavní řešitel

Pokročilé povlaky
- odpovědné pracoviště (19.12.2024 - nezadáno)
Pokročilé povlaky
- příjemce (19.12.2024 - nezadáno)

Odpovědnost: Montufar Jiménez Edgar Benjamin, M.Sc., Ph.D.