Detail publikace

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

DRAŽANOVÁ, E. RUDÁ-KUČEROVÁ, J. KRÁTKÁ, L. STARK, T. KUCHAŘ, M. MARYŠKA, M. DRAGO, F. STARČUK, Z. MICALE, V.

Originální název

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim of this study was to assess cerebral blood perfusion in several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker BioSpec 94/30USR scanner) in rats. In this study, prenatal exposure to methylazoxymethanol acetate (MAM, 22 mg/kg) at gestational day (GD) 17 and the perinatal treatment with Delta-9-tetrahydrocannabinol (THC, 5 mg/kg) from GD15 to postnatal day 9 elicited behavioral deficits consistent with schizophrenia-like phenotype, which is in agreement with the neurodevelopmental hypothesis of schizophrenia. In MAM exposed rats a significant enlargement of lateral ventricles and perfusion changes (i.e.: increased blood perfusion in the circle of Willis and sensorimotor cortex and decreased perfusion in hippocampus) were detected. On the other hand, the THC perinatally exposed rats did not show differences in the cerebral blood perfusion in any region of interest. These results suggest that although both pre/perinatal insults showed some of the schizophrenia-like deficits, these are not strictly related to distinct hemodynamic features.

Klíčová slova

methylazoxymethanol acetate; animal-models; brain structure; cannabis use; schizophrenia; flow; metaanalysis; symptoms; delta(9)-tetrahydrocannabinol; delta-9-tetrahydrocannabinol

Autoři

DRAŽANOVÁ, E.; RUDÁ-KUČEROVÁ, J.; KRÁTKÁ, L.; STARK, T.; KUCHAŘ, M.; MARYŠKA, M.; DRAGO, F.; STARČUK, Z.; MICALE, V.

Vydáno

15. 4. 2019

Nakladatel

Springer Nature

Místo

LONDON

ISSN

2045-2322

Periodikum

Scientific Reports

Ročník

9

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

10

Strany počet

10

URL

https://www.nature.com/articles/s41598-019-42532-z

Plný text v Digitální knihovně

http://hdl.handle.net/11012/202970

BibTex

@article{BUT169903,
  author="Eva {Dražanová} and Jana {Rudá-Kučerová} and Lucie {Krátká} and Tibor {Stark} and Martin {Kuchař} and Michal {Maryška} and Filippo {Drago} and Zenon {Starčuk} and Vincenzo {Micale}",
  title="Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats",
  journal="Scientific Reports",
  year="2019",
  volume="9",
  number="1",
  pages="1--10",
  doi="10.1038/s41598-019-42532-z",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-019-42532-z"
}