Publication detail

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

DRAŽANOVÁ, E. RUDÁ-KUČEROVÁ, J. KRÁTKÁ, L. STARK, T. KUCHAŘ, M. MARYŠKA, M. DRAGO, F. STARČUK, Z. MICALE, V.

Original Title

Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats

Type

journal article in Web of Science

Language

English

Original Abstract

Clinical studies consistently report structural impairments (i.e.: ventricular enlargement, decreased volume of anterior cingulate cortex or hippocampus) and functional abnormalities including changes in regional cerebral blood flow in individuals suffering from schizophrenia, which can be evaluated by magnetic resonance imaging (MRI) techniques. The aim of this study was to assess cerebral blood perfusion in several schizophrenia-related brain regions using Arterial Spin Labelling MRI (ASL MRI, 9.4 T Bruker BioSpec 94/30USR scanner) in rats. In this study, prenatal exposure to methylazoxymethanol acetate (MAM, 22 mg/kg) at gestational day (GD) 17 and the perinatal treatment with Delta-9-tetrahydrocannabinol (THC, 5 mg/kg) from GD15 to postnatal day 9 elicited behavioral deficits consistent with schizophrenia-like phenotype, which is in agreement with the neurodevelopmental hypothesis of schizophrenia. In MAM exposed rats a significant enlargement of lateral ventricles and perfusion changes (i.e.: increased blood perfusion in the circle of Willis and sensorimotor cortex and decreased perfusion in hippocampus) were detected. On the other hand, the THC perinatally exposed rats did not show differences in the cerebral blood perfusion in any region of interest. These results suggest that although both pre/perinatal insults showed some of the schizophrenia-like deficits, these are not strictly related to distinct hemodynamic features.

Keywords

methylazoxymethanol acetate; animal-models; brain structure; cannabis use; schizophrenia; flow; metaanalysis; symptoms; delta(9)-tetrahydrocannabinol; delta-9-tetrahydrocannabinol

Authors

DRAŽANOVÁ, E.; RUDÁ-KUČEROVÁ, J.; KRÁTKÁ, L.; STARK, T.; KUCHAŘ, M.; MARYŠKA, M.; DRAGO, F.; STARČUK, Z.; MICALE, V.

Released

15. 4. 2019

Publisher

Springer Nature

Location

LONDON

ISBN

2045-2322

Periodical

Scientific Reports

Year of study

9

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

10

Pages count

10

URL

https://www.nature.com/articles/s41598-019-42532-z

Full text in the Digital Library

http://hdl.handle.net/11012/202970

BibTex

@article{BUT169903,
  author="Eva {Dražanová} and Jana {Rudá-Kučerová} and Lucie {Krátká} and Tibor {Stark} and Martin {Kuchař} and Michal {Maryška} and Filippo {Drago} and Zenon {Starčuk} and Vincenzo {Micale}",
  title="Different effects of prenatal MAM vs. perinatal THC exposure on regional cerebral blood perfusion detected by Arterial Spin Labelling MRI in rats",
  journal="Scientific Reports",
  year="2019",
  volume="9",
  number="1",
  pages="1--10",
  doi="10.1038/s41598-019-42532-z",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-019-42532-z"
}