Detail publikačního výsledku

Tools for Time-Course Simulation in Systems Biology: A Brief Overview

MUSILOVÁ, J.; SEDLÁŘ, K.

Originální název

Tools for Time-Course Simulation in Systems Biology: A Brief Overview

Anglický název

Tools for Time-Course Simulation in Systems Biology: A Brief Overview

Druh

Článek WoS

Originální abstrakt

Dynamic modeling of biological systems is essential for understanding all properties of a given organism as it allows us to look not only at the static picture of an organism but also at its behavior under various conditions. With the increasing amount of experimental data, the number of tools that enable dynamic analysis also grows. However, various tools are based on different approaches, use different types of data, and offer different functions for analyses, so it can be difficult to choose the most suitable tool for a selected type of model. Here, we bring a brief overview containing descriptions of 50 tools for the reconstruction of biological models, their time-course simulation, and dynamic analysis. We examined each tool using test data and divided them based on the qualitative and quantitative nature of the mathematical apparatus they use.

Anglický abstrakt

Dynamic modeling of biological systems is essential for understanding all properties of a given organism as it allows us to look not only at the static picture of an organism but also at its behavior under various conditions. With the increasing amount of experimental data, the number of tools that enable dynamic analysis also grows. However, various tools are based on different approaches, use different types of data, and offer different functions for analyses, so it can be difficult to choose the most suitable tool for a selected type of model. Here, we bring a brief overview containing descriptions of 50 tools for the reconstruction of biological models, their time-course simulation, and dynamic analysis. We examined each tool using test data and divided them based on the qualitative and quantitative nature of the mathematical apparatus they use.

Klíčová slova

dynamic model; biological networks; qualitative; quantitative; hybrid

Klíčová slova v angličtině

dynamic model; biological networks; qualitative; quantitative; hybrid

Autoři

MUSILOVÁ, J.; SEDLÁŘ, K.

Rok RIV

2022

Vydáno

11.01.2021

ISSN

1477-4054

Periodikum

BRIEFINGS IN BIOINFORMATICS

Svazek

22

Číslo

5

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

15

Strany počet

15

URL

https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa392/6076933?guestAccessKey=ad7949aa-346e-421c-a28d-669d5874a590

BibTex

@article{BUT166211,
  author="Jana {Musilová} and Karel {Sedlář}",
  title="Tools for Time-Course Simulation in Systems Biology: A Brief Overview",
  journal="BRIEFINGS IN BIOINFORMATICS",
  year="2021",
  volume="22",
  number="5",
  pages="1--15",
  doi="10.1093/bib/bbaa392",
  issn="1467-5463",
  url="https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa392/6076933?guestAccessKey=ad7949aa-346e-421c-a28d-669d5874a590"
}