Publication detail

Tools for Time-Course Simulation in Systems Biology: A Brief Overview

MUSILOVÁ, J. SEDLÁŘ, K.

Original Title

Tools for Time-Course Simulation in Systems Biology: A Brief Overview

Type

journal article in Web of Science

Language

English

Original Abstract

Dynamic modeling of biological systems is essential for understanding all properties of a given organism as it allows us to look not only at the static picture of an organism but also at its behavior under various conditions. With the increasing amount of experimental data, the number of tools that enable dynamic analysis also grows. However, various tools are based on different approaches, use different types of data, and offer different functions for analyses, so it can be difficult to choose the most suitable tool for a selected type of model. Here, we bring a brief overview containing descriptions of 50 tools for the reconstruction of biological models, their time-course simulation, and dynamic analysis. We examined each tool using test data and divided them based on the qualitative and quantitative nature of the mathematical apparatus they use.

Keywords

dynamic model; biological networks; qualitative; quantitative; hybrid

Authors

MUSILOVÁ, J.; SEDLÁŘ, K.

Released

11. 1. 2021

ISBN

1477-4054

Periodical

Briefings in Bioinformatics

Year of study

22

Number

5

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

15

Pages count

15

URL

https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa392/6076933?guestAccessKey=ad7949aa-346e-421c-a28d-669d5874a590

BibTex

@article{BUT166211,
  author="Jana {Musilová} and Karel {Sedlář}",
  title="Tools for Time-Course Simulation in Systems Biology: A Brief Overview",
  journal="Briefings in Bioinformatics",
  year="2021",
  volume="22",
  number="5",
  pages="1--15",
  doi="10.1093/bib/bbaa392",
  issn="1477-4054",
  url="https://academic.oup.com/bib/advance-article/doi/10.1093/bib/bbaa392/6076933?guestAccessKey=ad7949aa-346e-421c-a28d-669d5874a590"
}