Detail publikace

Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery

ČERNOHLÁVEK, M. BRANDEJSOVÁ, M. ŠTĚPÁN, P. VÁGNEROVÁ, H. HERMANNOVÁ, M. KOPECKÁ, K. KULHÁNEK, J. NEČAS, D. VRBKA, M. VELEBNÝ, V. ANGELES, G.

Originální název

Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hyaluronan (HA) is widely used for eye drops as lubricant to counteract dry eye disease. High and low molecular weight HA are currently used in ophthalmology. However, a large portion of the current literature on friction and lubrication addresses articular (joint) cartilage. Therefore, eye drops compositions based on HA and its derivatized forms are extensively characterized providing data on the tribological and mucoadhesive properties. The physiochemical properties are investigated in buffers used commonly in eye drops formulations. The tribological investigation reveals that amphiphilic HA-C12 decreases the friction coefficient. At the same time, the combination of trehalose/HA or HAC12 enhances up to eighty-fold the mucoadhesiveness. Thus, it is predicted a prolonged residence time on the surface of the eye. The incorporation of trehalose enhances the protection of human keratinocytes (HaCaT) cells, as demonstrated in an in-vitro cell-desiccation model. The presence of trehalose increases the friction coefficient. Medium molecular weight HA shows significantly lower friction coefficient than high molecular weight HA. This research represents a first, wide array of features of diverse HA forms for eye drops contributing to increase the knowledge of these preparations. The results here presented also provide valuable information for the design of highly performing HA-formulations addressing specific needs before preclinic.

Klíčová slova

hyaluronan; biotribology; friction; lubrication; eye drops

Autoři

ČERNOHLÁVEK, M.; BRANDEJSOVÁ, M.; ŠTĚPÁN, P.; VÁGNEROVÁ, H.; HERMANNOVÁ, M.; KOPECKÁ, K.; KULHÁNEK, J.; NEČAS, D.; VRBKA, M.; VELEBNÝ, V.; ANGELES, G.

Vydáno

30. 9. 2021

Nakladatel

MDPI

Místo

Basilej, Švýcarsko

ISSN

2218-273X

Periodikum

Biomolecules

Ročník

11

Číslo

10

Stát

Švýcarská konfederace

Strany od

1431

Strany do

1431

Strany počet

15

URL

https://www.mdpi.com/2218-273X/11/10/1431/htm

Plný text v Digitální knihovně

http://hdl.handle.net/11012/203067

BibTex

@article{BUT173155,
  author="Mikuláš {Černohlávek} and Martina {Brandejsová} and Petr {Štěpán} and Hana {Vágnerová} and Martina {Hermannová} and Kateřina {Kopecká} and Jaromír {Kulhánek} and David {Nečas} and Martin {Vrbka} and Vladimír {Velebný} and Gloria Huerta {Angeles}",
  title="Insight into the Lubrication and Adhesion Properties of Hyaluronan for Ocular Drug Delivery",
  journal="Biomolecules",
  year="2021",
  volume="11",
  number="10",
  pages="1431--1431",
  doi="10.3390/biom11101431",
  issn="2218-273X",
  url="https://www.mdpi.com/2218-273X/11/10/1431/htm"
}