Detail publikace

Injecting hyaluronan in the thoracolumbar fascia: A model study

NEŠPOROVÁ, K. MATONOHOVÁ, J. HUSBY, J. TOROPITSYN, E. DIVOKÁ STUPECKÁ, L. HUSBY, A. SUCHÁNKOVÁ KLEPLOVÁ, T. STREĎANSKÁ, A. ŠIMEK, M. NEČAS, D. VRBKA, M. SCHLEIP, R. VELEBNÝ, V.

Originální název

Injecting hyaluronan in the thoracolumbar fascia: A model study

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hyaluronan (HA) has been recently identified as a key component of the densification of thoracolumbar fascia (TLF), a potential contributor to non-specific lower back pain (LBP) currently treated with manual therapy and systemic or local delivery of anti-inflammatory drugs. The aim of this study was to establish a novel animal model suitable for studying ultrasound-guided intrafascial injection prepared from HA with low and high Mw. Effects of these preparations on the profibrotic switch and mechanical properties of TLF were measured by qPCR and rheology, respectively, while their lubricating properties were evaluated by tribology. Rabbit proved to be a suitable model of TLF physiology due to its manageable size enabling both TLF extraction and in situ intrafascial injection. Surprisingly, the tribology showed that low Mw HA was a better lubricant than the high Mw HA. It was also better suited for intrafascial injection due to its lower injection force and ability to freely spread between TLF layers. No profibrotic effects of either HA preparation in the TLF were observed. The intrafascial application of HA with lower MW into the TLF appears to be a promising way how to increase the gliding of the fascial layers and target the myofascial LBP.

Klíčová slova

Hyaluronan, Thoracolumbar fascia, Intrafascial injection

Autoři

NEŠPOROVÁ, K.; MATONOHOVÁ, J.; HUSBY, J.; TOROPITSYN, E.; DIVOKÁ STUPECKÁ, L.; HUSBY, A.; SUCHÁNKOVÁ KLEPLOVÁ, T.; STREĎANSKÁ, A.; ŠIMEK, M.; NEČAS, D.; VRBKA, M.; SCHLEIP, R.; VELEBNÝ, V.

Vydáno

31. 12. 2023

Nakladatel

Elsevier

Místo

Amsterdam, Nizozemsko

ISSN

0141-8130

Periodikum

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ročník

253

Číslo

3

Stát

Nizozemsko

Strany od

126879

Strany do

126879

Strany počet

11

URL

https://www.sciencedirect.com/science/article/pii/S0141813023037765?dgcid=coauthor

BibTex

@article{BUT184942,
  author="NEŠPOROVÁ, K. and MATONOHOVÁ, J. and HUSBY, J. and TOROPITSYN, E. and DIVOKÁ STUPECKÁ, L. and HUSBY, A. and SUCHÁNKOVÁ KLEPLOVÁ, T. and STREĎANSKÁ, A. and ŠIMEK, M. and NEČAS, D. and VRBKA, M. and SCHLEIP, R. and VELEBNÝ, V.",
  title="Injecting hyaluronan in the thoracolumbar fascia: A model study",
  journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES",
  year="2023",
  volume="253",
  number="3",
  pages="11",
  doi="10.1016/j.ijbiomac.2023.126879",
  issn="0141-8130",
  url="https://www.sciencedirect.com/science/article/pii/S0141813023037765?dgcid=coauthor"
}