Detail publikačního výsledku

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging

ŠURÁŇOVÁ, M.; ĎURIŠ, M.; ŠTENGLOVÁ NETÍKOVÁ, I.; BRÁBEK, J.; HORÁK, T.; JŮZOVÁ, V.; CHMELÍK, R.; VESELÝ, P.

Originální název

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging

Anglický název

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging

Druh

Článek WoS

Originální abstrakt

Solid tumor metastases cause most cancer-related deaths. The prevention of their occurrence misses suitable anti-metastases medicines newly labeled as migrastatics. The first indication of migrastatics potential is based on an inhibition of in vitro enhanced migration of tumor cell lines. Therefore, we decided to develop a rapid test for qualifying the expected migrastatic potential of some drugs for repurposing. The chosen Q-PHASE holographic microscope provides reliable multifield time-lapse recording and simultaneous analysis of the cell morphology, migration, and growth. The results of the pilot assessment of the migrastatic potential exerted by the chosen medicines on selected cell lines are presented.

Anglický abstrakt

Solid tumor metastases cause most cancer-related deaths. The prevention of their occurrence misses suitable anti-metastases medicines newly labeled as migrastatics. The first indication of migrastatics potential is based on an inhibition of in vitro enhanced migration of tumor cell lines. Therefore, we decided to develop a rapid test for qualifying the expected migrastatic potential of some drugs for repurposing. The chosen Q-PHASE holographic microscope provides reliable multifield time-lapse recording and simultaneous analysis of the cell morphology, migration, and growth. The results of the pilot assessment of the migrastatic potential exerted by the chosen medicines on selected cell lines are presented.

Klíčová slova

In-vitro; Multi-field; Quantitative phase imaging; Rapid test; Repurposing; Simultaneous analysis; Solid tumors; Time-lapse recording; Tumor cell lines; Tumor metastasis

Klíčová slova v angličtině

In-vitro; Multi-field; Quantitative phase imaging; Rapid test; Repurposing; Simultaneous analysis; Solid tumors; Time-lapse recording; Tumor cell lines; Tumor metastasis

Autoři

ŠURÁŇOVÁ, M.; ĎURIŠ, M.; ŠTENGLOVÁ NETÍKOVÁ, I.; BRÁBEK, J.; HORÁK, T.; JŮZOVÁ, V.; CHMELÍK, R.; VESELÝ, P.

Rok RIV

2024

Vydáno

01.06.2023

Nakladatel

Optica

ISSN

2156-7085

Periodikum

Biomedical Optics Express

Svazek

14

Číslo

6

Stát

Spojené státy americké

Strany od

2689

Strany do

2708

Strany počet

20

URL

https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-6-2689&id=530666

Plný text v Digitální knihovně

http://hdl.handle.net/11012/213614

BibTex

@article{BUT183847,
  author="Markéta {Šuráňová} and Miroslav {Ďuriš} and Irena {Štenglová Netíková} and Jan {Brábek} and Tomáš {Horák} and Veronika {Jůzová} and Radim {Chmelík} and Pavel {Veselý}",
  title="Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging",
  journal="Biomedical Optics Express",
  year="2023",
  volume="14",
  number="6",
  pages="2689--2708",
  doi="10.1364/BOE.488630",
  issn="2156-7085",
  url="https://opg.optica.org/boe/fulltext.cfm?uri=boe-14-6-2689&id=530666"
}