Detail publikačního výsledku

p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system

PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.

Originální název

p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system

Anglický název

p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system

Druh

Abstrakt

Originální abstrakt

Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.

Anglický abstrakt

Protein p53 is one of the most studied tumour suppressor proteins, plays important roles in regulating basic biological processes. The human p53 gene contains alternative promoters and thanks to alternative splicing could be expressed in several isoforms. P53 protein function is realized by DNA-binding and transactivation of target genes. In this paper results of p53alpha isoform DNA interaction studies by yeast isogenic system for in vivo transactivation studies in chromosomal context were presented.

Klíčová slova

p53alpha isoforms, yeast isogenic system, cruciforms

Klíčová slova v angličtině

p53alpha isoforms, yeast isogenic system, cruciforms

Autoři

PORUBIAKOVÁ, O.; BRÁZDA, V.; BOHÁLOVÁ, N.

Vydáno

07.05.2019

BibTex

@misc{BUT157762,
  author="Otília {Porubiaková} and Václav {Brázda} and Natália {Bohálová}",
  title="p53alpha protein isoforms binds preferentially to cruciform in transactivation yeast isogenic system",
  year="2019",
  note="Abstract"
}