Detail publikace

Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

KHEZRI, B. MOHSEN BELADI, M. KREJČOVÁ, L. HEGER, Z. SOFER, Z. PUMERA, M.

Originální název

Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Nano/micromachines with autonomous motion are the frontier of nanotechnology and nanomaterial research. These self-propelled nano/micromachines convert chemical energy obtained from their surroundings to propulsion. They have shown great potential in diagnostic and therapeutic applications. This work introduces a high-speed tubular electrically conductive micromachine based on reduced nanographene oxide (n-rGO) as a platform for drug delivery and platinum (Pt) as the catalytic inner layer. n-rGO/Pt micromachines are loaded with doxorubicin (DOX) by a simple physical adsorption with a very high loading efficiency, displaying single- or multistrand wrapping of DOX monomers on the micromachine cylinders. More importantly, it is found that electron injection into DOX@n-rGO/Pt micromachines via electrochemistry leads to expulsion of DOX from micromachines in motion within only a few seconds. An in vitro study confirms this efficient release mechanism in the presence of cancerous cells. The unique properties of the n-rGO/Pt micromotor enable the effective management of DOX release at the tumor site and thus enhances the therapeutic efficiency and reduces the side toxicity toward the healthy tissue. These micromachine drug carriers combine the high loading capacity of conventional carbon-based drug carriers with a fast and efficient electrochemical drug-release mechanism.

Klíčová slova

doxorubicin; drug delivery; electrochemical release; micromotors; reduced graphene oxide

Autoři

KHEZRI, B.; MOHSEN BELADI, M.; KREJČOVÁ, L.; HEGER, Z.; SOFER, Z.; PUMERA, M.

Vydáno

24. 1. 2019

ISSN

1616-301X

Periodikum

ADVANCED FUNCTIONAL MATERIALS

Ročník

29

Číslo

4

Stát

Spolková republika Německo

Strany od

1

Strany do

10

Strany počet

10

URL

https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806696

BibTex

@article{BUT156116,
  author="Bahareh {Khezri} and Mousavi {Mohsen Beladi} and Ludmila {Krejčová} and Zbyněk {Heger} and Zdeněk {Sofer} and Martin {Pumera}",
  title="Ultrafast Electrochemical Trigger Drug Delivery Mechanism for Nanographene Micromachines",
  journal="ADVANCED FUNCTIONAL MATERIALS",
  year="2019",
  volume="29",
  number="4",
  pages="1--10",
  doi="10.1002/adfm.201806696",
  issn="1616-301X",
  url="https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201806696"
}