Detail publikace

Patterns of diffusion kurtosis changes in Parkinson's disease subtypes

SEJNOHA MINSTEROVÁ, A. KLOBUŠIAKOVÁ, P. PIES, A. GALÁŽ, Z. MEKYSKA, J. NOVÁKOVÁ, L. NĚMCOVÁ ELFMARKOVÁ, N. REKTOROVÁ, I.

Originální název

Patterns of diffusion kurtosis changes in Parkinson's disease subtypes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Background: Diffusion kurtosis imaging has been applied to evaluate white matter and basal ganglia microstructure in mixed Parkinson's disease (PD) groups with inconclusive results. Objectives: To evaluate specific patterns of kurtosis changes in PD and to assess the utility of diffusion imaging in differentiating between healthy subjects and cognitively normal PD, and between PD with and without mild cognitive impairment. Methods: Diffusion scans were obtained in 92 participants using 3T MRI. Differences in white matter were tested by tract-based spatial statistics. Gray matter was evaluated in basal ganglia, thalamus, hippocampus, and motor and premotor cortices. Brain atrophy was also assessed. Multivariate logistic regression was used to identify a combination of diffusion parameters with the highest discrimination power between groups. Results: Diffusion kurtosis metrics showed a significant increase in substantia nigra (p = 0.037, Hedges' g = 0.89), premotor (p = 0.009, Hedges' g = 0.85) and motor (p = 0.033, Hedges' g = 0.87) cortices in PD with normal cognition compared to healthy participants. Combined diffusion markers in gray matter reached 81% accuracy in differentiating between both groups. Significant white matter microstructural changes, and kurtosis decreases in the cortex were present in cognitively impaired versus cognitively normal PD. Diffusion parameters from white and gray matter differentiated between both PD phenotypes with 78% accuracy. Conclusions: Increased kurtosis in gray matter structures in cognitively normal PD reflects increased hindrance to water diffusion caused probably by alpha-synuclein-related microstructural changes. In cognitively impaired PD, the changes are mostly driven by decreased white matter integrity. Our results support the utility of diffusion kurtosis imaging for PD diagnostics.

Klíčová slova

MRI; diffusion kurtosis imaging; Parkinson's disease; mild cognitive impairment; diagnostic marker

Autoři

SEJNOHA MINSTEROVÁ, A.; KLOBUŠIAKOVÁ, P.; PIES, A.; GALÁŽ, Z.; MEKYSKA, J.; NOVÁKOVÁ, L.; NĚMCOVÁ ELFMARKOVÁ, N.; REKTOROVÁ, I.

Vydáno

19. 10. 2020

Nakladatel

Elsevier

ISSN

1353-8020

Periodikum

PARKINSONISM & RELATED DISORDERS

Ročník

81

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

96

Strany do

102

Strany počet

7

URL

https://www.prd-journal.com/article/S1353-8020(20)30825-7/fulltext

Plný text v Digitální knihovně

http://hdl.handle.net/11012/195850

BibTex

@article{BUT165726,
  author="Alžběta {Minsterová} and Patrícia {Klobušiaková} and Adrián {Pieš} and Zoltán {Galáž} and Jiří {Mekyska} and Ľubomíra {Nováková} and Nela {Elfmarkova} and Irena {Rektorová}",
  title="Patterns of diffusion kurtosis changes in Parkinson's disease subtypes",
  journal="PARKINSONISM & RELATED DISORDERS",
  year="2020",
  volume="81",
  number="1",
  pages="96--102",
  doi="10.1016/j.parkreldis.2020.10.032",
  issn="1353-8020",
  url="https://www.prd-journal.com/article/S1353-8020(20)30825-7/fulltext"
}