Detail publikace

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

WU, Q. YOU, L. NEPOVIMOVÁ, E. HEGER, Z. WU, W. KUČA, K. ADAM, V.

Originální název

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have demonstrated that hypoxia and hypoxia-inducible factors (HIFs) 1 and 2 alpha (HIF1A and HIF2A) are involved in tumor immune escape. Under hypoxia, activation of HIF1A induces a series of signaling events, including through programmed death receptor-1/programmed death ligand-1. Moreover, hypoxia triggers shedding of complex class I chain-associated molecules through nitric oxide signaling impairment to disrupt immune surveillance by natural killer cells. The HIF-1-galactose-3-O-sulfotransferase 1-sulfatide axis enhances tumor immune escape via increased tumor cell-platelet binding. HIF2A upregulates stem cell factor expression to recruit tumor-infiltrating mast cells and increase levels of cytokines interleukin-10 and transforming growth factor-beta, resulting in an immunosuppressive tumor microenvironment. Additionally, HIF1A upregulates expression of tumor-associated long noncoding RNAs and suppresses immune cell function, enabling tumor immune escape. Overall, elucidating the underlying mechanisms by which HIFs promote evasion of tumor immune surveillance will allow for targeting HIF in tumor treatment. This review discusses the current knowledge of how hypoxia and HIFs facilitate tumor immune escape, with evidence to date implicating HIF1A as a molecular target in such immune escape. This review provides further insight into the mechanism of tumor immune escape, and strategies for tumor immunotherapy are suggested.

Klíčová slova

Hypoxia; Hypoxia-inducible factors; Tumor disease; Immunotherapy; Personalized medicine

Autoři

WU, Q.; YOU, L.; NEPOVIMOVÁ, E.; HEGER, Z.; WU, W.; KUČA, K.; ADAM, V.

Vydáno

3. 6. 2022

Nakladatel

BioMed Central

Místo

LONDON

ISSN

1756-8722

Periodikum

Journal of Hematology & Oncology

Ročník

15

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

18

Strany počet

18

URL

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01292-6

Plný text v Digitální knihovně

http://hdl.handle.net/11012/208185

BibTex

@article{BUT178439,
  author="Qinghua {Wu} and Li {You} and Eugenie {Nepovimová} and Zbyněk {Heger} and Wenda {Wu} and Kamil {Kuča} and Vojtěch {Adam}",
  title="Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape",
  journal="Journal of Hematology & Oncology",
  year="2022",
  volume="15",
  number="1",
  pages="1--18",
  doi="10.1186/s13045-022-01292-6",
  issn="1756-8722",
  url="https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01292-6"
}