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HRABĚTA, J. ADAM, V. ECKSCHLAGER, T. FREI, E. STIBOROVÁ, M. KIZEK, R.
Originální název
Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
The history of metal based cytostatics began in the 1970s by discovering the effects of cisplatin. Since then several generations of platinum based cytostatics have started to be the key weapon against tumor development and metastasis occurrence. Nevertheless, some attention has been also paid to non-platinum metals, such as ruthenium, titanium, gallium, iron, cobalt, gold, and palladium. Ruthenium, titanium, and gallium complexes have been also tested in clinical studies. This boom in metal based cytostatics can be explained by great effort paid to the elucidation of mechanisms of tumor resistance to these drugs. The known mechanisms of drug resistance are: (i) down regulation, over-expression, or modification of molecules of interest; (ii) increased drug efflux; (iii) induction of anti-apoptotic mechanisms or inactivation of pro-apoptotic mechanisms; (iv) changes in enzymes with an ability to activate or detoxify a drug; (v) low access of the drug to a tumor; and/or (vi) alteration in drug metabolism or excretion [1]. Often discussed but not largely reviewed and summarized is the intracellular inactivation of platinum drugs by coordination to thiol containing biomolecules glutathione (GSH) and metallothioneins (MTs). Overexpression of MT and/or GSH may cause resistance to anticancer drugs. Thus, greater attention should be paid to these interactions in case to overcome the resistance of tumor to cytostatics.
Klíčová slova
Metal-containing cytostatic drugs, platinum, resistance, chemoresistance, glutathione, metallothioneins
Autoři
HRABĚTA, J.; ADAM, V.; ECKSCHLAGER, T.; FREI, E.; STIBOROVÁ, M.; KIZEK, R.
Vydáno
1. 1. 2016
ISSN
1871-5206
Periodikum
Anti-Cancer Agents in Medicinal Chemistry
Ročník
16
Číslo
6
Stát
Stát Spojené arabské emiráty
Strany od
686
Strany do
698
Strany počet
13
BibTex
@article{BUT127800, author="Jan {Hraběta} and Vojtěch {Adam} and Tomáš {Eckschlager} and Eva {Frei} and Marie {Stiborová} and René {Kizek}", title="Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance", journal="Anti-Cancer Agents in Medicinal Chemistry", year="2016", volume="16", number="6", pages="686--698", doi="10.2174/1871520616666151120122611", issn="1871-5206" }