Combined study

4 years

prof. Ing. Miloslav Pekař, CSc.

Chairman :
prof. Ing. Miloslav Pekař, CSc.
Vice-chairman :
prof. RNDr. Ivana Márová, CSc.
Councillor internal :
doc. Ing. Filip Mravec, Ph.D.
prof. Ing. Martina Klučáková, Ph.D.
prof. Ing. Adriána Kovalčík, Ph.D.
prof. Ing. Stanislav Obruča, Ph.D.
Councillor external :
prof. RNDr. Jaroslav Turánek, CSc.
Ing. Lukáš Nejdl, Ph.D.
prof. RNDr. Dalibor Štys, CSc.
prof. RNDr. Zbyněk Zdráhal, Dr.
prof. Mgr. Marek Koutný, Ph.D.

1. Modelling of transport phenomena in biological environment

   The development of various drug delivery systems is an area of active research. This research is focused mainly on chemical, biochemical, or physiological aspects. The movement of a delivery system in human body, to the point of the drug action is much less investigated. The drug transport to the targeted site where the drug’s chemical action should take place is essential for its proper function. This study will be therefore aimed at mathematical modeling of this transport based either on published data or data collected at the supervisor’s laboratory. The work will be focused on the modeling of the diffusion of nano- and microparticles in model biological medium, especially in hydrogel or similar model of the extracellular matrix, or through biological membrane. These tasks will be solved using COMSOL packet. The tasks include also the construction of realistic structural model of the environment, embracing 3D structural features of real biological environments or of real tissues, and the modelling support of the microrheological experiments in hydrogels performed in the laboratory where this PhD study will be realized. The aim of this study is obtaining a feedback for the design of the drug delivery systems.

   Tutor: Klučáková Martina, prof. Ing., Ph.D.

2. Study of the behaviour of crystalline active substances on a long-term time scale

   Study of stability and physicochemical phenomena of biologically active substances associated with their long-term storage. In particular, thermal analysis, powder rheology and microscopy methods will be used for this purpose.

   Tutor: Enev Vojtěch, doc. Ing., Ph.D.