1. History of Medical Imaging - first look to different imaging modalities, basic physical principles related to development of imaging systems, quantitative and qualitative parameters of medical imaging, image quality assessment.
2. Physics of ionizing radiation - electromagnetic radiationy, atom and its models, electron transitions, characteristic radiation and Auger electron emission, nuclear stability, radioactivity, interactions of radiation with matter (all kinds), attenuation of radiation.
3. X-Ray Systems 1 - geometric acquisition, summated imaging, x-ray tube - basic principle, characteristic radiation, Bremsstrahlung, types of x-ray tubes, materials for anodes, X-Ray generators, filtration and collimation of the radiation, primary collimator.
4. X-Ray Systems  2 - scattered radiation, Bucky grid, anti-scatter grid, detection of X-Ray - photographic film, computed digital radiography (memory foils), flat panels with direct and indirect detection of radiation, specifications for fluoroscopy - image intensifier, different acquisition parameters.
5. X-Ray Systems 3 - nontypical applications - fluoroscopy, using of contrast agents, mammography, dental X-Ray, bone densitometry, dual energy acquisition, 3D digital tomosynthesis, image quality of X-Ray Systems.
6. CT systems 1 - tomographic systems, basic principles - parallel projections, image reconstruction, algebraic reconstruction, simple back projection, filtered back projection, iterative reconstructions, fan beam projections, helical data interpolation, multi-layer detectors interpolations, definition of CT number.
7. CT systems 2- historical overview of CT systems and generations - first, second, third, slip ring technology, fourth and fifth generation, helical systems, sub-secund systems, multi-layer systems. X-Ray tubes for CT systems - differences to standard X-Ray tubes.
8. CT systems 3 - detection of radiation in CT - gas detectors, scintillators, technologies for production of multi-layer detectors. Acquisition parameters - anode voltage, anode current, helical pitch, binning. Technical perspective of CT system components - gantry, patient table and others. Image quality of CT systems.
9. Nuclear Medicine Imaging 1 - radionuclides as a source of ionizing radiation, gamma radiation, summation imaging - planar scintigraphy, Anger's camera,  detection by semiconductors - Cadmium-Zinc-Telluride (CZT) detector.
10. Nuclear Medicine Imaging 2 - tomographic systems - single photon emission computed tomography (SPECT), positron emission tomography (PET) - definitions, projections, set of projections, image reconstructions, coincidence, time-of-flight detection and reconstructions, typical radiopharmaceuticals (technetium 99m, FDG, etc.).
11. Hybrid Medical Imaging - construction, combination of selected imaging modalities - advantages, disadvantages, correction of attenuation, SPECT-CT, PET-CT, PET-MRI, unusual combinations for preclinical research. Theranostics - basic principle of method, clinical examples.
12. Radiation biology - dose, negative effects of ionizing radiation to tissue, limitations of radiation dose, simulations of radiation protection.  

Set of tasks for PC lab: 

1. Simulation of attenuation of x-ray with various energies, simulation of Compton scattering.
2. Simulation of X-ray spectra - effect of various anode voltage, anode current and material filtration.
3. Image reconstruction for computed tomography - sinogram, simple back projection, filtered back projection.
4. Advanced method for image reconstruction - iterative approaches, SIRT, SART, etc.
5. Principles of PET imaging - positron annihilation, two photons propagation and detection, sinogram estimation, time of flight (TOF). 
6. Pharmacokinetic modeling in PET data analysis - overview of models, design of own model, extraction of time intensity curves, analysis.

Excursion to a clinical facility working with imaging systems using ionizing radiation. 

1. Basics of X-ray imaging - image geometry, spatial resolution.
2. Spectrum of X-ray tube - combination of characteristic radiation and bremsstrahlung.
3. Computed tomography - acquisition of data, representation by sinogram, image reconstruction.
4. Image detector properties - measuring of dark current noise characteristic, linearization of photons to image level conversion. 
5. Basic measurement with radioactive tracers - alpha, beta, gamma radioactivity, inverse square law.