Czech

5

Not applicable.

Knowledges in the field on Special toxicology - toxicology of elements, hazardous metals, inorganic, organic and complex compounds. Biotransformation of of Xenobiotics. Toxicity of Environmental Pollutants. Toxic agents, poison in food, nature. Carcinogenesis, mutagenesis, teratogenesis, Oxidative Stress. Product safety and actual legislative of chemicals.

Basic knowledges of general toxicology, inorganic, organic chemistry, environmental chemistry, biochemistry.

Not applicable.

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Examination - written and oral part.

1. Introduction of Special Toxikology, Contents, Terminology, Principles (Exposure, Dose, Toxicity, Limits).
2. The interaction of toxic compounds wit organism. Manifestations of molecular, cell and organ toxicity.
3. Xenobiochemistry. The fate of chemical compounds in organism, pathways of toxic compounds and metabolites.
4. Toxicology of elements, hazardous metals, inorganic compounds, mechanism of interactions of metals in body. Metal transport and metabolism.
5. Toxicology organic and organometallic compounds.
6. Environmental pollutants. Industrial toxicology.
7. Toxicity in foods, additives, dyes,toxicants resulting from food processing.
8. Effects of fungal and mushroom, plant, animal toxins on human body. Important toxins of microbes (bakteria, micromycota), fungi (edible, nonedible), plants, animals. Metabolites of plants, animals. Toxicological important micro and macromycetes.
9. Carcinogenesis, mutagenesis, teratogenesis (molecular mechanism of processes, inhibitors, inductors, natural and synthetic mutagenic and carcinogenic agents), Teratogenesis, teratogene.
10. The oxidative stress, reactive oxygen species (ROS) - free radicals, reactive anions, source, effects, antioxidant protection.
11. Radiotoxicology. Biophysical/biological effector mechanisms, and health effects of radionuclides. Chemical warfare agents.
12. Product safety, International monitoring of hazardous groups of chemicals and materials. The classification of chemical compounds in CZ and EU, actual legislative of chemicals.

Not applicable.

Getting deeper knowledges of toxicology of elements, hazardous metals, inorganic, organic and complex compounds. Biotransformation of of Xenobiotics. The enlargement of environmental pollutants, industrial toxicology. The presence of toxic agents, poison in food, nature. The elucidation of processes of Carcinogenesis, mutagenesis, teratogenesis, Oxidative Stress. Basic information of product safety and actual legislative of chemicals.

Consultations for students in distant form.
Consultations for students.

Not applicable.

Not applicable.

Timbrell, J. A., Introduction to Toxicology. Taylor and Francis, London, 1995; (CS)
Hodgson, E., Levi P. E., A Textbook of Modern Toxicology, Elsevier Sci. Publ., New York, Amsterdam, London, 1987 (CS)
Tichý, M., Toxikologie pro chemiky. Universita Karlova, Praha, 2002 (CS)

Not applicable.

26 hours, optionally