Detail publikačního výsledku

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; SZABOVÁ, J.; LÍZAL, F.

Original Title

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

English Title

Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer

Type

Paper in proceedings (conference paper)

Original Abstract

Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.

English abstract

Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.

Keywords

Aerosol, particle size, nebulizuer, flow rate, liposom

Key words in English

Aerosol, particle size, nebulizuer, flow rate, liposom

Authors

MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; SZABOVÁ, J.; LÍZAL, F.

RIV year

2023

Released

29.11.2022

Publisher

EDP Sciences

Location

Dvůr Králové nad Labem

Book

Proceedings of the International Conference Experimental Fluid Mechanics 2022

ISBN

2101-6275

Periodical

EPJ web of conferences (Print)

State

French Republic

Pages count

4

URL

https://www.epj-conferences.org/articles/epjconf/abs/2024/09/epjconf_efm2024_01029/epjconf_efm2024_01029.html

Full text in the Digital Library

http://hdl.handle.net/

BibTex

@inproceedings{BUT180626,
  author="Ondrej {Mišík} and Milan {Malý} and Ondřej {Cejpek} and Jana {Szabová} and František {Lízal}",
  title="Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer",
  booktitle="Proceedings of the International Conference Experimental Fluid Mechanics 2022",
  year="2022",
  journal="EPJ web of conferences (Print)",
  pages="4",
  publisher="EDP Sciences",
  address="Dvůr Králové nad Labem",
  doi="10.1051/epjconf/202429901029",
  issn="2101-6275",
  url="https://www.epj-conferences.org/articles/epjconf/abs/2024/09/epjconf_efm2024_01029/epjconf_efm2024_01029.html"
}