Publication detail

Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

EJNEBY, M. JAKEŠOVÁ, M. FERRERO, J. MIGLIACCIO, L. SAHALIANOV, I. ZHAO, Z. BERGGREN, M. KHODAGHOLY, D. DEREK, V. GELINAS, J. GLOWACKI, E.

Original Title

Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor

Type

journal article in Web of Science

Language

English

Original Abstract

Implantable devices for the wireless modulation of neural tissue need to be designed for reliability, safety and reduced invasiveness. Here we report chronic electrical stimulation of the sciatic nerve in rats by an implanted organic electrolytic photocapacitor that transduces deep-red light into electrical signals. The photocapacitor relies on commercially available semiconducting non-toxic pigments and is integrated in a conformable 0.1-mm(3) thin-film cuff. In freely moving rats, fixation of the cuff around the sciatic nerve, 10 mm below the surface of the skin, allowed stimulation (via 50-1,000-mu s pulses of deep-red light at wavelengths of 638 nm or 660 nm) of the nerve for over 100 days. The robustness, biocompatibility, low volume and high-performance characteristics of organic electrolytic photocapacitors may facilitate the wireless chronic stimulation of peripheral nerves. An organic electrolytic photocapacitor transducing deep-red light into electrical signals and implanted within a thin cuff around the sciatic nerve of rats allows for wireless electrical stimulation of the nerve for over 100 days.

Keywords

NEURAL STIMULATION; SAFETY; ELECTRODE; EFFICACY; POWER

Authors

EJNEBY, M.; JAKEŠOVÁ, M.; FERRERO, J.; MIGLIACCIO, L.; SAHALIANOV, I.; ZHAO, Z.; BERGGREN, M.; KHODAGHOLY, D.; DEREK, V.; GELINAS, J.; GLOWACKI, E.

Released

22. 11. 2021

Publisher

Springer Nature

Location

BERLIN

ISBN

2157-846X

Periodical

Nature Biomedical Engineering

Year of study

6

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

741

Pages to

753

Pages count

16

URL

https://www.nature.com/articles/s41551-021-00817-7

Full text in the Digital Library

http://hdl.handle.net/11012/208151

BibTex

@article{BUT176503,
  author="Malin Silverå {Ejneby} and Marie {Jakešová} and Jose J. {Ferrero} and Ludovico {Migliaccio} and Ihor {Sahalianov} and Zifang {Zhao} and Magnus {Berggren} and Dion {Khodagholy} and Vedran {Derek} and Jennifer N. {Gelinas} and Eric Daniel {Glowacki}",
  title="Chronic electrical stimulation of peripheral nerves via deep-red light transduced by an implanted organic photocapacitor",
  journal="Nature Biomedical Engineering",
  year="2021",
  volume="6",
  number="1",
  pages="741--753",
  doi="10.1038/s41551-021-00817-7",
  issn="2157-846X",
  url="https://www.nature.com/articles/s41551-021-00817-7"
}