Publication detail

Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

VAVERKA, J. MOUDR, J. LOKAJ, P. BURŠA, J. PÁSEK, M.

Original Title

Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study

Type

journal article in Web of Science

Language

English

Original Abstract

This study investigates the impact of reduced transmural conduction velocity (TCV) on output parameters of the human heart. In a healthy heart, the TCV contributes to synchronization of the onset of contraction in individual layers of the left ventricle (LV). However, it is unclear whether the clinically observed decrease of TCV contributes significantly to a reduction of LV contractility. The applied three-dimensional finite element model of isovolumic contraction of the human LV incorporates transmural gradients in electromechanical delay and myocyte shortening velocity and evaluates the impact of TCV reduction on pressure rise (namely, (dP/dt)(max)) and on isovolumic contraction duration (IVCD) in a healthy LV. The model outputs are further exploited in the lumped “Windkessel” model of the human cardiovascular system (based on electrohydrodynamic analogy of respective differential equations) to simulate the impact of changes of (dP/dt)(max) and IVCD on chosen systemic parameters (ejection fraction, LV power, cardiac output, and blood pressure). The simulations have shown that a 50% decrease in TCV prolongs substantially the isovolumic contraction, decelerates slightly the LV pressure rise, increases the LV energy consumption, and reduces the LV power. These negative effects increase progressively with further reduction of TCV. In conclusion, these results suggest that the pumping efficacy of the human LV decreases with lower TCV due to a higher energy consumption and lower LV power. Although the changes induced by the clinically relevant reduction of TCV are not critical for a healthy heart, they may represent an important factor limiting the heart function under disease conditions.

Keywords

heart contraction, left ventricle, finite element model, blood circuit simulation, conduction velocity

Authors

VAVERKA, J.; MOUDR, J.; LOKAJ, P.; BURŠA, J.; PÁSEK, M.

Released

4. 4. 2020

Publisher

Hindawi

Location

London, United Kingdom

ISBN

2314-6133

Periodical

BioMed Research International

Year of study

2020

Number

1

State

United States of America

Pages from

1

Pages to

11

Pages count

11

URL

https://www.hindawi.com/journals/bmri/2020/2867865/

Full text in the Digital Library

http://hdl.handle.net/11012/188044

BibTex

@article{BUT163683,
  author="Jiří {Vaverka} and Jiří {Moudr} and Petr {Lokaj} and Jiří {Burša} and Michal {Pásek}",
  title="Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study",
  journal="BioMed Research International",
  year="2020",
  volume="2020",
  number="1",
  pages="1--11",
  doi="10.1155/2020/2867865",
  issn="2314-6133",
  url="https://www.hindawi.com/journals/bmri/2020/2867865/"
}