We propose a novel concept of a “Faraday’s scalpel”: an approach to deoxygenate brain tissue using electrocatalytic oxygen reduction and direct electrical currents. The hypothesis is that local hypoxia induced by the Faraday Scalpel electrode will selectively destroy neurons while preserving other cells, opening new possibilities for precise electrosurgery for conditions like epilepsy. This proposal has three objectives: A) optimize two types of faradaic electrodes: one for hypoxia, and another for hypoxia plus hydrogen peroxide generation; B) develop multifunctional electronic/optical implantable probes to deoxygenate tissue while allowing in situ characterization of oxygen level, tissue morphology, and electrophysiology. C) apply the concept in vivo to achieve hypoxic ablation, validated by measuring neural activity and optical/histological methods. The project is interdisciplinary, covering electrochemistry, microelectronics, physiology, and advanced optical imaging. Success of our project will create powerful tools for basic research and a promising approach for neurosurgery.

Keywords
bioelectronics;electrochemistry;reactive oxygen species;oxygen reduction reaction; electrophysiology

23-07432S

English

Glowacki Eric Daniel, prof., Ph.D. - principal person responsible

Bioelectronics Materials and Systems
- responsible department (31.3.2022 - not assigned)
Central European Institute of Technology BUT
- responsible department (31.3.2022 - 31.3.2022)
Bioelectronics Materials and Systems
- beneficiary (1.1.2023 - 31.12.2026)

MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E. Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry. CHEMBIOCHEM, 2023, vol. 24, no. 17, p. 1-14. ISSN: 1439-7633.
Detail

EHLICH, J.; VAŠÍČEK, Č.; DOBEŠ, J.; RUGGIERO, A.; VEJVODOVÁ, M.; GLOWACKI, E. Shattering the Water Window: Comprehensive Mapping of Faradaic Reactions on Bioelectronics Electrodes. ACS Applied Materials & Interfaces, 2024, vol. 16, no. 40, p. 53567-53576. ISSN: 1944-8252.
Detail

GRYSZEL, M.; JAKEŠOVÁ, M.; VU, X.; INGEBRANDT, S.; GLOWACKI, E. Elevating Platinum to Volumetric Capacitance: High Surface Area Electrodes through Reactive Pt Sputtering. Advanced Healthcare Materials, 2024, vol. 13, no. 5, 7 p. ISSN: 2192-2640.
Detail

JAKEŠOVÁ, M.; KUNOVSKÝ, O.; GABLECH, I.; KHODAGHOLY, D.; GELINAS, J.; GLOWACKI, E. Coupling of photovoltaics with neurostimulation electrodes-optical to electrolytic transduction. Journal of Neural Engineering, 2024, vol. 21, no. 4, 13 p. ISSN: 1741-2552.
Detail

GABLECH, I.; GLOWACKI, E. State-of-the-Art Electronic Materials for Thin Films in Bioelectronics. Advanced Electronic Materials, 2023, vol. 9, no. 8, p. 1-23. ISSN: 2199-160X.
Detail

Responsibility: Glowacki Eric Daniel, prof., Ph.D.