Publication result detail

Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry

MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E.

Original Title

Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry

English Title

Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry

Type

WoS Article

Original Abstract

Reactive oxygen species (ROS) are an integral part of many anticancer therapies. Fenton-like processes involving reactions of peroxides with transition metal ions are a particularly potent and tunable subset of ROS approaches. Precise on-demand dosing of the Fenton reaction is an area of great interest. Herein, we present a concept of an electrochemical faradaic pixel that produces controlled amounts of ROS via a Fenton-like process. The pixel comprises a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide. The anode is made of chromium, which is electrochemically corroded to yield chromium ions. Peroxide and chromium interact to form a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. After benchmarking the electrochemical properties of this type of device, we demonstrate how it can be used under in vitro conditions with a cancer cell line. The faradaic Fenton pixel is a general and scalable concept that can be used for on-demand delivery of redox-active products for controlling a physiological outcome.

English abstract

Reactive oxygen species (ROS) are an integral part of many anticancer therapies. Fenton-like processes involving reactions of peroxides with transition metal ions are a particularly potent and tunable subset of ROS approaches. Precise on-demand dosing of the Fenton reaction is an area of great interest. Herein, we present a concept of an electrochemical faradaic pixel that produces controlled amounts of ROS via a Fenton-like process. The pixel comprises a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide. The anode is made of chromium, which is electrochemically corroded to yield chromium ions. Peroxide and chromium interact to form a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. After benchmarking the electrochemical properties of this type of device, we demonstrate how it can be used under in vitro conditions with a cancer cell line. The faradaic Fenton pixel is a general and scalable concept that can be used for on-demand delivery of redox-active products for controlling a physiological outcome.

Keywords

bioelectronics; Fenton reaction; oxygen reduction reaction; reactive oxygen species

Key words in English

bioelectronics; Fenton reaction; oxygen reduction reaction; reactive oxygen species

Authors

MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E.

RIV year

2024

Released

01.09.2023

Publisher

Wiley-VCH

Location

WEINHEIM

ISBN

1439-7633

Periodical

CHEMBIOCHEM

Volume

24

Number

17

State

Federal Republic of Germany

Pages from

1

Pages to

14

Pages count

14

URL

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353

Full text in the Digital Library

http://hdl.handle.net/11012/245065

BibTex

@article{BUT184657,
  author="Eva {Miglbauer} and Oliya S. {Abudllaeva} and Maciej {Gryszel} and Eric Daniel {Glowacki}",
  title="Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry",
  journal="CHEMBIOCHEM",
  year="2023",
  volume="24",
  number="17",
  pages="1--14",
  doi="10.1002/cbic.202300353",
  issn="1439-4227",
  url="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353"
}

Documents

2023-Miglbauer