This thesis solves design of intrchange R 46 and II/428 near Vyškov, more exactly specified in the village Drysice. In the existing situation is not resolved connecting lanes and turning lanes at the interchange. This causes reduced road safety, which leads to a significant number of traffic accidents in this section. The thesis solves design respectively modification substandard connecting and turning lanes on all parts of flyover crossroads with associated modifications of two bridges. Integral part of the proposed modification is the elimination of existing noise load in the village, by using of noise barriers.