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Bachelor's Thesis
Author of thesis: Ivana Škorubová
Acad. year: 2025/2026
Supervisor: Ing. Jiří Smilek, Ph.D.
Reviewer: Ing. Martin Kadlec, Ph.D.
This bachelor’s thesis focuses on the preparation, optimization, and characterization of semi-interpenetrating hydrogel systems based on poly(ethylene glycol) diacrylate. The aim of the thesis was to describe the effect of composition on the resulting mechanical and transport properties of the hydrogels. In the experimental section, the radical photopolymerization of poly(ethylene glycol) diacrylate-based hydrogels with polymer concentrations of 3, 4, and 5 wt.% was first optimized. Subsequently, semi-interpenetrating hydrogel systems were prepared by incorporating sodium polystyrene sulfonate or DEAE-dextran into the poly(ethylene glycol) diacrylate matrix. The mechanical and viscoelastic behavior of the materials was characterized using dynamic mechanical analysis. Amplitude tests were used to define the linear viscoelastic region of the prepared hydrogels. an increase in the elastic modulus was observed as the concentration of poly(ethylene glycol) diacrylate increased. The structural characterization of the prepared polymer networks was further studied by observing the hydrogel’s swelling properties. This observation highlighted the diversity of the prepared polymer networks, which was most evident at a 5 wt.% concentration of poly(ethylene glycol) diacrylate. The transport section of this thesis observed the transport 4 rate of dyes such as fluorescein and rhodamine 6G through the network, and these observations were compared between simple poly(ethylene glycol) diacrylate-based hydrogels and semi-interpenetrating hydrogels. The obtained experimental data provide valuable information for further research with potential applications in tissue engineering and controlled-release drug delivery systems.
Hydrogels, semi-interpenetrating polymer networks, polyethylene glycol diacrylate, photopolymerization, rheology, viscoelasticity, dynamic mechanical analysis
Date of defence
10.06.2026
Result of the defence
Defended (thesis was successfully defended)
Grading
A
Process of defence
Obhajoba proběhla podle následujícího schématu: prezentace studentky-vyjádření vedoucí/ho-oponentský posudek-reakce na posudek-diskuse s komisí. Studentka přednesla výborný výtah výsledků své bakalářské práce, řádně zodpověděla všechny dotazy oponentské i členů komise, pohotově reagovala na připomínky. V diskusi tak studentka prokázala výbornou schopnost orientace v teoretických i praktických základech problematiky bakalářské práce. Komise zhodnotila její bakalářskou práci celkově jako výbornou. Pekař: Kolik se přidávalo PSS a dextranu a jaké byly jejich hmotnosti? Jak vypadal hydrogel vizuálně? Jak probíhal experiment s Petriho miskami? Dzik: Jak vypadají data mezi 450 a 600 s?
Language of thesis
Slovak
Faculty
Fakulta chemická
Department
Institute of Physical and Applied Chemistry
Study programme
Chemistry for Medical Application (BPCP_CHMA)
Composition of Committee
prof. Ing. Miloslav Pekař, CSc. (předseda) doc. Ing. Zdenka Kozáková, Ph.D. (člen) prof. Ing. Stanislav Obruča, Ph.D. (místopředseda) doc. Ing. Vojtěch Enev, Ph.D. (člen) doc. Ing. Petr Dzik, Ph.D. (člen)
Supervisor’s reportIng. Jiří Smilek, Ph.D.
Grade proposed by supervisor: A
Reviewer’s reportIng. Martin Kadlec, Ph.D.
Grade proposed by reviewer: A
Responsibility: Mgr. et Mgr. Hana Odstrčilová