Přístupnostní navigace
E-application
Search Search Close
Course detail
FEKT-MPAN-TBIAcad. year: 2027/2028
The course “Cell and Tissie Engineering” provides an overview of the principles, methods, technologies, and instrumentation used in the field of cellular and tissue engineering, particularly in laboratory and research settings and in the context of regenerative medicine. The course focuses on the fundamental principles underlying the design, fabrication, and evaluation of systems for controlling cellular behavior and developing functional tissue structures.
The course covers biomaterials used in cellular and tissue engineering, their properties, interactions with cells, and methods for their characterization. It further addresses the principles of tissue scaffold design and fabrication, cell culture techniques, and the use of bioreactors. Particular attention is given to stem cells, cellular differentiation, and mechanotransduction, as well as their role in regulating tissue regeneration and formation.
A dedicated part of the course focuses on strategies for the engineering of selected tissues, including vascular, skin, bone, and cartilage tissues, as well as on the use of advanced culture systems, including organ-on-a-chip technologies. The course also introduces advanced methods for the characterization of biomaterials, cells, and cell–material interactions.
The final part of the course addresses the translation of cellular and tissue engineering approaches into clinical practice, including fundamental principles of safety and efficacy assessment, regulatory requirements, and ethical aspects related to the development and application of engineered tissues.
Language of instruction
Number of ECTS credits
Mode of study
Guarantor
Department
Entry knowledge
Rules for evaluation and completion of the course
The final course grade will be determined based on the points obtained from the credit test (maximum of 10 points) and the final oral examination (maximum of 90 points).
To obtain the course credit, students must meet the following requirements:
Only students who have been awarded the course credit are eligible to take the final examination.
Detailed requirements for the successful completion of the course are specified in the annually updated directive issued by the course coordinator.
Aims
1 – Cell and Tissue Engineering Fundamentals
2 – Biomaterials in Tissue Engineering
3 – Scaffold Design & Fabrication for Tissue Engineering
4 – Cell Culture Techniques & Bioreactors
5 – Stem Cells in Regenerative Medicine
6 – Mechanotransduction in Cell Engineering
7 – Blood Vessel and Skin Tissue Engineering
8 – Bone and Cartilage Tissue Engineering
9 – Organ–on–a–Chip Systems
10 – Cell-biomaterial Interaction and Characterization
11 – Characterization Techniques of Biomaterials and Cells
12 – Clinical Translation & Regulatory Aspects
Study aids
Cell Culture and Tissue Engineering, Wujie Zhang, Springer Cham, Published: 28 August 2026. https://doi.org/10.1007/978-3-032-32096-4
Prerequisites and corequisites
Basic literature
Recommended reading
Classification of course in study plans
specialization MPC-BIO_TECH , 2 year of study, summer semester, compulsory-optional
Lecture
Teacher / Lecturer
Syllabus
Laboratory exercise
1. Cultivation of cells. Preparation of hydrogel and seeding of cells on hydrogel. Degradation of hydrogel.
2. Swelling of hydrogel. Evaluation of hydrogel swelling and degradation. Microscopic evaluation of cells on hydrogel (VIS, fluorescence).
3. Basic of Fusion 360. Virtual reality for Fusion model. 3D printing and segmentation (Slicer) in cardiology + practical 3D printing.
Individual preparation for a final exam
Individual preparation for laboratories
Students are provided with prepared study materials for each laboratory. They are expected to study these materials independently in advance and, if necessary, look for additional information in lecture presentations or use other sources.