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Course detail
FEKT-MPA-BTIAcad. year: 2026/2027
This course provides a comprehensive overview of the principles and methodologies of cellular and tissue engineering with a focus on applications in regenerative medicine. It covers the fundamentals of biomaterials used in tissue engineering, scaffold design and fabrication, cell culture techniques, and the use of bioreactors. The course further addresses the role of stem cells, mechanotransduction processes, and strategies for engineering vascular, skin, bone, and cartilage tissues, as well as organ-on-chip systems. Emphasis is placed on cell–biomaterial interactions, advanced characterization techniques for biomaterials and cells, and the clinical translation of engineered tissues, including regulatory and ethical considerations.
Language of instruction
Number of ECTS credits
Mode of study
Guarantor
Department
Entry knowledge
Basic knowledge of biology.
Rules for evaluation and completion of the course
Lecture – final test
Practical sessions – 100% attendance required
Aims
1 – Cell and Tissue Engineering Fundamentals
2 – Biomaterials in Tissue Engineering
3 – Scaffold Design & Fabrication for Tissue Engineering
4 – Cell Culture Techniques & Bioreactors
5 – Stem Cells in Regenerative Medicine
6 – Mechanotransduction in Cell Engineering
7 – Blood Vessel and Skin Tissue Engineering
8 – Bone and Cartilage Tissue Engineering
9 – Organ–on–a–Chip Systems
10 – Cell-biomaterial Interaction and Characterization
11 – Characterization Techniques of Biomaterials and Cells
12 – Clinical Translation & Regulatory Aspects
Study aids
1. Haraguchi Y, Shimizu T, Yamato M, Okano T. Concise review: cell therapy and tissue engineering for cardiovascular disease. Stem Cells Transl Med. 2012 Feb;1(2):136-41. Epub 2012 Jan 26. PMID: 23197760; PMCID: PMC3659688.
2. Cheng, B., Li, M., Lin, M. et al. Mechanobiology across timescales. Nat Rev Phys 7, 621–644 (2025).
3. Shiva Norouzi, Nikoo Saveh Shemshaki, Ehsan Norouzi, Masoud Latifi, Bahareh Azimi, Serena Danti, Xiaolan Qiao, Yuee Miao, Shengyuan Yang, Mohsen Gorji, Vasilije Petrovic, M. Ali Aboudzadeh, Roohollah Bagherzadeh, Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques, Materials Today Chemistry, Volume 37, 2024, 102016, ISSN 2468-5194,
4. Agarwal T, Onesto V, Banerjee D, Guo S, Polini A, Vogt C, Viswanath A, Esworthy T, Cui H, O'Donnell A, Vajanthri KY, Moroni L, Ozbolat IT, Panoskaltsis-Mortari A, Zhang LG, Costantini M, Maiti TK. 3D bioprinting in tissue engineering: current state-of-the-art and challenges towards system standardization and clinical translation. Biofabrication. 2025 Aug 7;17(4). PMID: 40513614.
Prerequisites and corequisites
Basic literature
Recommended reading
Lecture
Teacher / Lecturer
Syllabus
Laboratory exercise
1. Cultivation of cells. Preparation of hydrogel and seeding of cells on hydrogel. Degradation of hydrogel.
2. Swelling of hydrogel. Evaluation of hydrogel swelling and degradation. Microscopic evaluation of cells on hydrogel (VIS, fluorescence).
3. Basic of Fusion 360. Virtual reality for Fusion model. 3D printing and segmentation (Slicer) in cardiology + practical 3D printing.
Individual preparation for laboratories
Individual preparation for a final exam