Course detail

Technology in Cellular Engineering

FEKT-MPA-TBIAcad. year: 2026/2027

The course “Cell and Tissie Engineering” provides an overview of the principles, methods, technologies, and instrumentation used in the field of cellular and tissue engineering, particularly in laboratory and research settings and in the context of regenerative medicine. The course focuses on the fundamental principles underlying the design, fabrication, and evaluation of systems for controlling cellular behavior and developing functional tissue structures.

The course covers biomaterials used in cellular and tissue engineering, their properties, interactions with cells, and methods for their characterization. It further addresses the principles of tissue scaffold design and fabrication, cell culture techniques, and the use of bioreactors. Particular attention is given to stem cells, cellular differentiation, and mechanotransduction, as well as their role in regulating tissue regeneration and formation.

A dedicated part of the course focuses on strategies for the engineering of selected tissues, including vascular, skin, bone, and cartilage tissues, as well as on the use of advanced culture systems, including organ-on-a-chip technologies. The course also introduces advanced methods for the characterization of biomaterials, cells, and cell–material interactions.

The final part of the course addresses the translation of cellular and tissue engineering approaches into clinical practice, including fundamental principles of safety and efficacy assessment, regulatory requirements, and ethical aspects related to the development and application of engineered tissues.

Language of instruction

English

Number of ECTS credits

5

Mode of study

Not applicable.

Offered to foreign students

Of all faculties

Entry knowledge

Knowledge of biology, mathematics and physics accordant with the subjects of previous bachelor’s study is expected.

Rules for evaluation and completion of the course

The final assessment for the course will be based on the points obtained from the credit test (10 points maximum) and the final oral examination (90 points maximum).

To obtain course credit, students must meet the following requirements:

  • 100% attendance in practical classes

  • passing the credit test (7/10 points)

Only students who have been awarded course credit may take the final examination.

The detailed requirements for successfully completing the course are specified in the course coordinator’s regulations, which are updated annually.

Aims

The aim of the course is to provide students with knowledge of technologies and methods used in laboratories focused on cell and tissue engineering. 

Study aids

Lecture materials are available and a range of recommended literature and materials are available. 

Alberts B., Johnson A., Walter P.: Molecular Biology of the Cell. (CS)
Ankur Singh, Akhilesh K. Gaharwar: Microscale Technologies for Cell Engineering (CS)
Bengt Nölting: Methods in Modern Biophysics (CS)
José Luis R. Arrondo, Alicia Alonso: Advanced Techniques in Biophysics. (CS)

Prerequisites and corequisites

Not applicable.

Basic literature

Alberts B., Johnson A., Walter P.: Molecular Biology of the Cell. (CS)
Ankur Singh, Akhilesh K. Gaharwar: Microscale Technologies for Cell Engineering (CS)
Bengt Nölting: Methods in Modern Biophysics (CS)
José Luis R. Arrondo, Alicia Alonso: Advanced Techniques in Biophysics. (CS)

Recommended reading

Not applicable.

Classification of course in study plans

  • Programme MPC-BTB Master's 0 year of study, summer semester, elective
  • Programme MPC-BIO Master's 2 year of study, summer semester, compulsory
  • Programme MPAD-BIO Master's 2 year of study, summer semester, compulsory, profile core courses
  • Programme MPA-BIO Master's 2 year of study, summer semester, compulsory, profile core courses

Type of course unit

 

Lecture

26 hours, optionally

Teacher / Lecturer

Syllabus

1 – Cell and Tissue Engineering Fundamentals

2 – Biomaterials in Tissue Engineering

3 – Scaffold Design & Fabrication for Tissue Engineering

4 – Cell Culture Techniques & Bioreactors

5 – Stem Cells in Regenerative Medicine

6 – Mechanotransduction in Cell Engineering

7 – Blood Vessel and Skin Tissue Engineering

8 – Bone and Cartilage Tissue Engineering

9 – Organ–on–a–Chip Systems

10 – Cell-biomaterial Interaction and Characterization

11 – Characterization Techniques of Biomaterials and Cells

12 – Clinical Translation & Regulatory Aspects

Exercise in computer lab

13 hours, compulsory

Teacher / Lecturer

Laboratory exercise

13 hours, compulsory

Teacher / Lecturer

Syllabus

  1. Basic of Fusion 360. Virtual reality for Fusion model. 3D printing and segmentation (Slicer) in cardiology + practical 3D printing.

  2. Preparation of hydrogel and seeding of cells on hydrogel. Degradation of hydrogel.

  3.  

    Swelling of hydrogel. Evaluation of hydrogel swelling and degradation. Microscopic evaluation of cells on hydrogel (VIS, fluorescence).