Course detail

Cellular and molecular neurobiology

CEITEC VUT-Bi9260Acad. year: 2025/2026

1. Use of model organisms for functional and developmental studies of nervous system (Drosophila, Xenopus, Aplysia, C. elegans, Mus musculus, tissue culture). 2. Neurons and neuroglial cells - morphology, function, mutual interaction. 3. Neuron signals - electrical activity, excitability, ion channels, synapses, neurotransmitters, neuromodulators, neuropeptides. 4. Cell signaling in nervous system - G-protein coupled receptors, cAMP, calcium signaling, protein phosphorylation and dephosphorylation. 5. Nervous system development, neurogenesis, neural stem cells, differentiation of neurons and glia, specific regulation of gene expression. 6. Brain development - homeotic genes, axon growth, axon pathfinding, synapsis formation. 7. Neuronal plasticity, synaptic plasticity, neuronal adaptation. 8. Biological basis of behaviour, biological clocks, emotion, pain, stress. 9. Sensory system, learning, memory. 10. Aging and death of neurons, neuronal regeneration, neuronal diseases, neuropharmacology. 

Language of instruction

English

Mode of study

Not applicable.

Department

Přírodovědecká fakulta (PřF MU)

Entry knowledge

Bi4020 Molecular biology
Principal knowledge of physiology, cell and molecular biology with focus on eukaryotic organisms. 

Rules for evaluation and completion of the course

Type of examination: written test which consists of 30 questions, 50% of correct answers is needed to pass. 

Aims

The aim of this lecture is to make students familiar with basic principles of nervous system function at the molecular and cellular level and to try to use this knowledge to understand the function of nervous system in the whole organism. 

Study aids

Not applicable.

Prerequisites and corequisites

Not applicable.

Basic literature

G. F. Striedter. Neurobiology A Functional Approach. Oxford University Press; 1 edition. 2015. 648 p. ISBN 978-0195396157 (EN)
G. L. Fain. Molecular and Cellular Physiology of Neurons, Second Edition. Harvard University Press, 752 p. 2014. ISBN 9780674599215 (EN)
Genetic dissection of neural circuits and behavior. Edited by S. F. Goodwin. Elsevier Inc., 2009, 199 p, ISBN 978-0-12-374836-2 (EN)
LUO, Liqun. Principles of neurobiology. 2nd ed. New York: Garland Science, 2020, 760 s. ISBN 9781003053972. (EN)
SANES, Dan H.; Thomas A. REH a William A. HARRIS. Development of the nervous system. 4th ed. San Diego: Academic Press, 2019, 390 s. ISBN 9780128039960. (EN)
The neurobiology of learning and memory. Edited by J. W. Rudy. Sinauer Associates, 2008, 380 p. ISBN 978-0-87893-669-4 (EN)

Recommended reading

Not applicable.