Course detail
Pathological Physiology
FEKT-APFYAcad. year: 2016/2017
Pathological physiology is a science about ethiology and pathogenesis of diseases and pathological states. The ability of pathophysiological thinking makes possible an insight into the logical basis of clinical manifest diseases and states in the participation of analytic and synthetic thought processes. Students will be introduced to the basic causes of illness (physical, chemical and biological, including genetic) and their pathogenetic context.
Language of instruction
Number of ECTS credits
Mode of study
Guarantor
Department
Learning outcomes of the course unit
- Can define the scope of pathophysiology
- Can explain the basic concepts of the issue of pathophysiology
- Can discuss the external factors leading to disease (physical, chemical and biological)
- Is able to discuss the nature of frequent pathologies and diseases
- Is able to explain the difference between a monogenic disease of civilization
- Can define the basic concepts of genetics
- Is able to define and discuss the basic concepts of the pathophysiology of various systems of the human organism
- Can explain the concepts of immunodeficiency, hypersensitivity and autoimmunity
Prerequisites
Co-requisites
Planned learning activities and teaching methods
Assesment methods and criteria linked to learning outcomes
Course curriculum
2. External factors leading to disease - physical, chemical and biological pathogenic factors.
3. The inflammation.
4. Cell and cellular interactions in the pathogenesis of the tissue damage. Wound healing. Malignant transformation.
5. Disorders of the immune system - immunodeficiency, hypersensitivity, autoimmunity.
6. Fundamentals of genetics - monogenic vs. diseases of civilization
7. Pathophysiology of hematopoiesis.
8. Pathophysiology of the cardiovascular system.
9. Pathophysiology of the respiratory system.
10. Pathophysiology of urinary system.
11. Pathophysiology of the digestive system.
12. Pathophysiology of hormones.
13. Pathophysiology of the nervous and muscular system.
Work placements
Aims
Specification of controlled education, way of implementation and compensation for absences
Recommended optional programme components
Prerequisites and corequisites
Basic literature
VAŠKŮ, Anna et al. Praktikum z patologické fyziologie. 1. vyd. Brno: MU Brno, 2000. ISBN 80-210-2318-X. (CS)
Recommended reading
Classification of course in study plans
Type of course unit
Lecture
Teacher / Lecturer
Syllabus
2. External factors of the origin of diseases – physical, chemical and biological pathogenic factors.
3. InflammationThe cell and cellular interactions in pathogenic tissue damage. Healing of wounds. Malignant transformation.
4. Immunity system disorders – immunodeficiency, hypersensitiveness, autoimmunity
5. Fundamentals of genetics – monogenous vs. civilisation diseases
6. Pathophysiology of hematogenesis
7. Pathophysiology of the cardiovascular system
8. Pathophysiology of the respiratory system
9. Pathophysiology of the excretory system
10. Pathophysiology of the digestive system
11. Pathophysiology of hormones
12. Pathophysiology of the nervous and muscular system
Laboratory exercise
Teacher / Lecturer
Syllabus
2. Radiation syndrome I
3. Radiation syndrome II
4. An experimental stomach ulcer
5. Renal ischemic disease
6. Experimental venous thrombosis
7. EKG and arythmia on animal models
8. Spirometric examination of lungs
9. Basics of DNA diagnostics - detection of I/D ACE polymorphism
10. Basics of hematological diagnostics
11. Experimental alloxane diabetes
12. Glucose tolerance test
13. Skin conductivity