Czech

4

Not applicable.

This course provides students especially the ability to:

Working with laboratory equipment and measuring instruments for conventional organic syntheses.
Experience with preaparation of organic substances in the laboratory scale.
Experience with occupational safety and health in the chemical laboratory work with organic compounds.

The knowledge of basic laboratory practices and techniques (recrystallization, distillation, extraction, etc.).

Not applicable.

Teaching methods depend on the type of course unit as specified in the article 7 of BUT Rules for Studies and Examinations.

Finish 11 laboratories at least, submit lab. reports and prepared compounds during the term.
Pass test(s) about practical and theoretical knowledges.

Students are briefed by organization of laboratory and syntheses in detail during the first lab. Safety training is also realized. Students realize at least 11 syntheses of the following:
1. 3-Nitroaniline (nitration and partial reduction of nitro compound)
2. Ethylbromide a tert-butylchloride (SN)
3. Ethyl acetate (esterification)
4. 2,4-Dinitrophenyl hydrazine and hid hydrazones (SNAr and preparation of hydrazone)
5. Benzilic acid (benzoin condenzation, oxidation of alcohole and benzylic reargement)
6. Chlorobenzene (diazotation and Sandmeyer reaction)
7. Anhydride of bicyclo[2.2.1]hept-2-ene-5,6-dicarboxylic acid and bicyclo[2.2.1]-hept-2-ene-5,6-dicarboxylic acid (Diels-Alder's reaction)
8. Phenacetine (acylation of amine and Wiliamson's reaction)
9. Acid Red 150 (diazotation and copulation)
10. ß -Nitrostyrene (10a) a 1,5-difenylpenta-1,4-dien-3-one (10b) (reaction of carbonyl compounds)
11. Diphenylmethanol (preparation and reaction of Grignard reagent)
12. 2-(-4-Toluoyl)benzoic acid (Friedel-Crafts reaction)
Labs at last week of the term are substitute for unqualified or sick students during the term.
Detailed manuals and literature for each task are available on https://www.vutbr.cz/elearning/course/view.php?id=121977

Not applicable.

Acquisition of the basic laboratory methods of the analysis and synthesis of organic substances.

Controlled personal attendance, lab. reports a test(s).

Not applicable.

Not applicable.

Kizlink J., Bednařík, K.: Návody pro laboratorní praktikum z organické chemie. VUT, Brno 2009. (CS)
https://www.vutbr.cz/elearning/course/view.php?id=121977 (CS)

Pazdera P., Potáček M.: Cvičení z metod organické chemie. MU, Brno 1997. (CS)
Sandler S.R., Karo W.: Sourcebook of Advanced Organic Laboratory Preparations. Academic Press, San Diego 1992. (CS)
Nováček E., Potáček M., Janků S.: Laboratorní technika ke cvičení z metod organické chemie. MU, Brno 2000. (CS)

78 hours, compulsory