A minireview on the bioinformatics analysis of mobile gene elements in microbiome research

A minireview on the bioinformatics analysis of mobile gene elements in microbiome research

Peer-reviewed article not indexed in WoS or Scopus

The horizontal transfer of mobile gene elements between bacteria plays a crucial role in their evolutionary dynamics. Additionally, it enables the accumulation and dissemination of genes conferring antibiotic and heavy-metal resistance, and thus contributes to the worldwide emergence and spread of drug-resistance pathogens. This process is instrumental in maintaining genetic diversity within bacterial populations and facilitates their adaptation to novel environments. It allows bacteria to acquire genes responsible for the synthesis of enzymes that utilize alternative energy sources and substrates. Furthermore, bacteria can acquire genes associated with toxin production and increased virulence. Horizontal gene transfer serves as a pivotal mechanism in bacterial evolution, enabling the acquisition of novel genetic information and enhancing their capabilities. However, the proper detection and identification of horizontally transferred genes at the microbiome scale is challenging, whether using wet-lab experime

The horizontal transfer of mobile gene elements between bacteria plays a crucial role in their evolutionary dynamics. Additionally, it enables the accumulation and dissemination of genes conferring antibiotic and heavy-metal resistance, and thus contributes to the worldwide emergence and spread of drug-resistance pathogens. This process is instrumental in maintaining genetic diversity within bacterial populations and facilitates their adaptation to novel environments. It allows bacteria to acquire genes responsible for the synthesis of enzymes that utilize alternative energy sources and substrates. Furthermore, bacteria can acquire genes associated with toxin production and increased virulence. Horizontal gene transfer serves as a pivotal mechanism in bacterial evolution, enabling the acquisition of novel genetic information and enhancing their capabilities. However, the proper detection and identification of horizontally transferred genes at the microbiome scale is challenging, whether using wet-lab experime

horizontal gene transfer, bacterial genomics, mobilome, microbiome, genome analysis

horizontal gene transfer, bacterial genomics, mobilome, microbiome, genome analysis

SCHWARZEROVÁ, J.; LABANAVA, A.; RYCHLÍK, I.; VARGA, M.; ČEJKOVÁ, D.

2024

11.10.2023

Frontiers

2813-6144

Frontiers in Bacteriology

2

1

United States of America

8

https://www.frontiersin.org/articles/10.3389/fbrio.2023.1275910/full

http://hdl.handle.net/11012/245103

fbrio-02-1275910