Publication detail

IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES

HRUBANOVÁ, A. LISICKÝ, O. BARTOŇOVÁ, P. STAFFA, R. HERMANOVÁ, M. VLACHOVSKÝ, R. BURŠA, J.

Original Title

IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES

English Title

IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES

Language

en

Original Abstract

Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.

English abstract

Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.

Keywords

Atherosclerotic plaque, Carotid artery, Mechanical properties, Uniaxial tensile test

Released

24.11.2020

ISBN

978-80-214-5896-3

Book

ENGINEERING MECHANICS 2020

Pages from

210

Pages to

213

Pages count

4

Documents

BibTex


@inproceedings{BUT166394,
  author="Anna {Hrubanová} and Ondřej {Lisický} and Petra {Bartoňová} and Robert {Staffa} and Markéta {Hermanová} and Robert {Vlachovský} and Jiří {Burša}",
  title="IMPACT OF FORMALDEHYDE ON MECHANICAL PROPERTIES OF ATHEROSCLEROTIC CAROTID ARTERIES",
  annote="Atherosclerosis is a life threatening cardiovascular disease causing lipoprotein accumulation within intima layer of artery wall and thus its thickening. Later stages are characterized by plaque formation with a lipid core separated from lumen by fibrous cap. In case of carotid arteries (CA), rupture of the plaque often results in a stroke. Detailed understanding of mechanical properties of atherosclerotic arteries and their components is essential for improvement of computer models used for prediction of plaque rupture. Samples of atherosclerotic CA from carotid endarterectomy were kept either in saline solution or in formaldehyde solution and then underwent uniaxial tensile testing in two directions. Statistical analysis of the obtained stress-strain responses shows that formaldehyde treatment of the tissue increases significantly the mean stiffness and reduces the dispersion.",
  booktitle="ENGINEERING MECHANICS 2020",
  chapter="166394",
  doi="10.21495/5896-3-210",
  howpublished="print",
  year="2020",
  month="november",
  pages="210--213"
}