Publication result detail

Comparative analysis of high butanol tolerance and production in clostridia

PATÁKOVÁ, P.; KOLEK, J.; SEDLÁŘ, K.; KOŠČOVÁ, P.; BRANSKÁ, B.; KUPKOVÁ, K.; PAULOVÁ, L.; PROVAZNÍK, I.

Original Title

Comparative analysis of high butanol tolerance and production in clostridia

English Title

Comparative analysis of high butanol tolerance and production in clostridia

Type

WoS Article

Original Abstract

All cellular responses elicited by butanol in solventogenic clostridia, such as modifications of cell envelope, formation of stress proteins, extrusion of butanol by efflux pumps, response of regulatory pathways, are reviewed. Further, both random and targeted mutations resulting in high butanol production phenotypes are described. Then a comparative analysis of both phenomena is presented and a theoretical relationship is found between butanol tolerance/high production which includes efflux pump activity, stress protein production, membrane modifications and biofilm growth. Progress in the methods, enabling a deeper understanding of butanol tolerance and production, is also reviewed.

English abstract

All cellular responses elicited by butanol in solventogenic clostridia, such as modifications of cell envelope, formation of stress proteins, extrusion of butanol by efflux pumps, response of regulatory pathways, are reviewed. Further, both random and targeted mutations resulting in high butanol production phenotypes are described. Then a comparative analysis of both phenomena is presented and a theoretical relationship is found between butanol tolerance/high production which includes efflux pump activity, stress protein production, membrane modifications and biofilm growth. Progress in the methods, enabling a deeper understanding of butanol tolerance and production, is also reviewed.

Keywords

Clostridium; ABE fermentation; butanol tolerance; butanol production; genome mining; transcriptomics

Key words in English

Clostridium; ABE fermentation; butanol tolerance; butanol production; genome mining; transcriptomics

Authors

PATÁKOVÁ, P.; KOLEK, J.; SEDLÁŘ, K.; KOŠČOVÁ, P.; BRANSKÁ, B.; KUPKOVÁ, K.; PAULOVÁ, L.; PROVAZNÍK, I.

RIV year

2018

Released

01.01.2018

Publisher

Elsevier

ISBN

0734-9750

Periodical

BIOTECHNOLOGY ADVANCES

Volume

35

Number

8

State

United Kingdom of Great Britain and Northern Ireland

Pages from

721

Pages to

738

Pages count

18

URL

https://www.sciencedirect.com/science/article/pii/S0734975017301568

BibTex

@article{BUT141763,
  author="Petra {Patáková} and Jan {Kolek} and Karel {Sedlář} and Pavlína {Cicková} and Barbora {Branská} and Kristýna {Kupková} and Leona {Paulová} and Valentýna {Provazník}",
  title="Comparative analysis of high butanol tolerance and production in clostridia",
  journal="BIOTECHNOLOGY ADVANCES",
  year="2018",
  volume="35",
  number="8",
  pages="721--738",
  doi="10.1016/j.biotechadv.2017.12.004",
  issn="0734-9750",
  url="https://www.sciencedirect.com/science/article/pii/S0734975017301568"
}