Publication result detail

The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease

ROY, S.; GUMULEC, J.; KUMAR, A.; RAUDENSKÁ, M.; BAIG, M.; POLANSKÁ, H.; BALVAN, J.; GUPTA, M.; BABULA, P.; ODSTRČILÍK, J.; CHOI, I.; PROVAZNÍK, I.; MASAŘÍK, M.

Original Title

The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease

English Title

The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease

Type

WoS Article

Original Abstract

Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.

English abstract

Metallothioneins (MTs) are a class of ubiquitously occurring low-molecular-weight cysteine- and metal-rich proteins containing sulfur-based metal clusters. MT-3 exhibits neuro-inhibitory activity. The possibility to enhance the expression of MT-3 or protect it from degradation is an attractive therapeutic target, because low levels of MT-3 were found in brains of Alzheimer's disease (AD) patients.

Keywords

Alzheimer’s Disease, Flow Cytometry, Immunodetection, Metallothionein-3, Molecular Dynamics, qRT-PCR

Key words in English

Alzheimer’s Disease, Flow Cytometry, Immunodetection, Metallothionein-3, Molecular Dynamics, qRT-PCR

Authors

ROY, S.; GUMULEC, J.; KUMAR, A.; RAUDENSKÁ, M.; BAIG, M.; POLANSKÁ, H.; BALVAN, J.; GUPTA, M.; BABULA, P.; ODSTRČILÍK, J.; CHOI, I.; PROVAZNÍK, I.; MASAŘÍK, M.

RIV year

2018

Released

15.08.2017

Publisher

Wiley Periodicals

Location

New York, USA

ISBN

2162-3279

Periodical

Brain and Behavior

Volume

7

Number

9

State

United States of America

Pages from

1

Pages to

9

Pages count

9

URL

http://onlinelibrary.wiley.com/doi/10.1002/brb3.799/abstract

Full text in the Digital Library

http://hdl.handle.net/11012/69945

BibTex

@article{BUT139120,
  author="Sudeep {Roy} and Jaromír {Gumulec} and Akhil {Kumar} and Martina {Raudenská} and Mohd Hassan {Baig} and Hana {Polanská} and Jan {Balvan} and Mansi {Gupta} and Petr {Babula} and Jan {Odstrčilík} and Inho {Choi} and Valentýna {Provazník} and Michal {Masařík}",
  title="The effect of Benzothiazolone-2 on the expression of Metallothionein-3 in modulating Alzheimer's disease",
  journal="Brain and Behavior",
  year="2017",
  volume="7",
  number="9",
  pages="1--9",
  doi="10.1002/brb3.799",
  issn="2162-3279",
  url="http://onlinelibrary.wiley.com/doi/10.1002/brb3.799/abstract"
}

Documents

Roy_et_al-2017-Brain_and_Behavior