Publication result detail

Multidimensional Correlated Mutation Analysis for Protein Contact Map Prediction

KUPKOVÁ, K.; SEDLÁŘ, K.; PROVAZNÍK, I.

Original Title

Multidimensional Correlated Mutation Analysis for Protein Contact Map Prediction

English Title

Multidimensional Correlated Mutation Analysis for Protein Contact Map Prediction

Type

Paper in proceedings (conference paper)

Original Abstract

Correlated mutation (CM) analysis has been proved to be an important tool used in protein contact map prediction from primary amino acid sequence. Over the last years CM methods have been refined and then often combined with methods of different nature in order to improve reached precision. However, since the methods are still relatively new, only precision and improvement have been reported without mentioning recall which is very low. In this paper, we combine previously described CM analysis methods with an outcome of four new techniques which significantly increase recall for the cost of minimal precision impairment. This study is the first of our knowledge with focus on recall improvement.

English abstract

Correlated mutation (CM) analysis has been proved to be an important tool used in protein contact map prediction from primary amino acid sequence. Over the last years CM methods have been refined and then often combined with methods of different nature in order to improve reached precision. However, since the methods are still relatively new, only precision and improvement have been reported without mentioning recall which is very low. In this paper, we combine previously described CM analysis methods with an outcome of four new techniques which significantly increase recall for the cost of minimal precision impairment. This study is the first of our knowledge with focus on recall improvement.

Keywords

Correlated mutations; Contact map; Protein structure prediction; Residue contact

Key words in English

Correlated mutations; Contact map; Protein structure prediction; Residue contact

Authors

KUPKOVÁ, K.; SEDLÁŘ, K.; PROVAZNÍK, I.

RIV year

2017

Released

26.05.2016

Publisher

Springer International Publishing

Location

Německo

ISBN

9783319399034

Book

Information Technologies in Medicine, 5th International Conference, ITIB 2016 Kamień Śląski, Poland, June 20 - 22, 2016 Proceedings, Volume 2

ISBN

2194-5357

Periodical

Advances in Intelligent Systems and Computing

Volume

472

Number

1

State

Swiss Confederation

Pages from

133

Pages to

144

Pages count

12

BibTex

@inproceedings{BUT126084,
  author="Kristýna {Kupková} and Karel {Sedlář} and Valentýna {Provazník}",
  title="Multidimensional Correlated Mutation Analysis for Protein Contact Map Prediction",
  booktitle="Information Technologies in Medicine, 5th International Conference, ITIB 2016 Kamień Śląski, Poland, June 20 - 22, 2016 Proceedings, Volume 2",
  year="2016",
  journal="Advances in Intelligent Systems and Computing",
  volume="472",
  number="1",
  pages="133--144",
  publisher="Springer International Publishing",
  address="Německo",
  doi="10.1007/978-3-319-39904-1\{_}12",
  isbn="9783319399034",
  issn="2194-5357"
}