Publication result detail

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

ŠKUTKOVÁ, H.; BABULA, P.; STIBOROVÁ, M.; ECKSCHLAGER, T.; TRNKOVÁ, L.; PROVAZNÍK, I.; HUBÁLEK, J.; KIZEK, R.; ADAM, V.

Original Title

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

English Title

Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review

Type

WoS Article

Original Abstract

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

English abstract

Mammalian metallothioneins (MTs) are cysteine-rich low-molecular mass proteins with numerous functions including toxic metal detoxification, as a metal chaperone and maintenance of metal ion homeostasis. Four major isoforms (MT-1 through MT-4) have been identified in mammals. In this review, the functions of the isoforms are summarized. Moreover, polymorphisms of MTs genes and their connection with cancerogenesis and cancer diagnostics are described. The interesting properties of MTs are closely related with structure, which can be studied by modern bioinformatics approaches and electrochemical methods. The advantages of the mentioned approaches and methods are discussed.

Keywords

Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H

Key words in English

Metallothionein; Isoforms; Bioinformatics; Data Analysis; Phylogeny; DNA Sequencing; Electrochemistry; Voltammetry; Brdicka Reaction; Peak H

Authors

ŠKUTKOVÁ, H.; BABULA, P.; STIBOROVÁ, M.; ECKSCHLAGER, T.; TRNKOVÁ, L.; PROVAZNÍK, I.; HUBÁLEK, J.; KIZEK, R.; ADAM, V.

RIV year

2013

Released

01.12.2012

ISBN

1452-3981

Periodical

International Journal of Electrochemical Science

Volume

2012

Number

7

State

Republic of Serbia

Pages from

12415

Pages to

12431

Pages count

16

BibTex

@article{BUT96584,
  author="Helena {Vítková} and Petr {Babula} and Marie {Stiborová} and Tomáš {Eckschlager} and Libuše {Trnková} and Valentýna {Provazník} and Jaromír {Hubálek} and René {Kizek} and Vojtěch {Adam}",
  title="Structure, Polymorphisms and Electrochemistry of Mammalian Metallothioneins – A Review",
  journal="International Journal of Electrochemical Science",
  year="2012",
  volume="2012",
  number="7",
  pages="12415--12431",
  issn="1452-3981"
}