Publication result detail

Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA

BABULA, P.; VANCO, J.; KREJČOVÁ, L.; HYNEK, D.; SOCHOR, J.; ADAM, V.; TRNKOVÁ, L.; HUBÁLEK, J.; KIZEK, R.

Original Title

Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA

English Title

Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA

Type

WoS Article

Original Abstract

Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we focused on electrochemical behaviour of seven newly prepared ternary copper(II) complexes of lawsone with additional O-donor (water) and N-donor ligands (pyridine, 2-, 3-, and 4-aminopyridine, 3-hydroxypyridine, and 3,5-dimethylpyrazole) using the methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA.

English abstract

Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we focused on electrochemical behaviour of seven newly prepared ternary copper(II) complexes of lawsone with additional O-donor (water) and N-donor ligands (pyridine, 2-, 3-, and 4-aminopyridine, 3-hydroxypyridine, and 3,5-dimethylpyrazole) using the methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA.

Keywords

Medicinal Chemistry; Nucleic Acid Interaction; Electrochemistry; Cyclic Voltammetry, Differential Pulse Voltammetry; Copper; Lawsone

Key words in English

Medicinal Chemistry; Nucleic Acid Interaction; Electrochemistry; Cyclic Voltammetry, Differential Pulse Voltammetry; Copper; Lawsone

Authors

BABULA, P.; VANCO, J.; KREJČOVÁ, L.; HYNEK, D.; SOCHOR, J.; ADAM, V.; TRNKOVÁ, L.; HUBÁLEK, J.; KIZEK, R.

RIV year

2013

Released

01.08.2012

ISBN

1452-3981

Periodical

International Journal of Electrochemical Science

Volume

7

Number

8

State

Republic of Serbia

Pages from

7349

Pages to

7366

Pages count

18

BibTex

@article{BUT95489,
  author="Petr {Babula} and Jan {Vanco} and Ludmila {Krejčová} and David {Hynek} and Jiří {Sochor} and Vojtěch {Adam} and Libuše {Trnková} and Jaromír {Hubálek} and René {Kizek}",
  title="Voltammetric Characterization of Lawsone-Copper(II) Ternary Complexes and Their Interactions with dsDNA",
  journal="International Journal of Electrochemical Science",
  year="2012",
  volume="7",
  number="8",
  pages="7349--7366",
  issn="1452-3981"
}