Publication result detail

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

ZÍTKA, O.; SKALIČKOVÁ, S.; GUMULEC, J.; MASAŘÍK, M.; ADAM, V.; HUBÁLEK, J.; TRNKOVÁ, L.; KIZEK, R.

Original Title

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

English Title

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Type

WoS Article

Original Abstract

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.

English abstract

Oxidative stress causes profound alterations of various biological structures, including cellular membranes, lipids, proteins and nucleic acids, and it is involved in numerous malignancies. Reduced glutathione (GSH) is considered to be one of the most important scavengers of reactive oxygen species (ROS), and its ratio with oxidised glutathione (GSSG) may be used as a marker of oxidative stress. The main aim of this study was to determine GSH:GSSG ratio in the blood serum of paediatric cancer patients to use this ratio as a potential marker of oxidative stress.

Keywords

glutathione, paediatric tumour patients, oxidative stress, high performance liquid chromatography with electrochemical detection

Key words in English

glutathione, paediatric tumour patients, oxidative stress, high performance liquid chromatography with electrochemical detection

Authors

ZÍTKA, O.; SKALIČKOVÁ, S.; GUMULEC, J.; MASAŘÍK, M.; ADAM, V.; HUBÁLEK, J.; TRNKOVÁ, L.; KIZEK, R.

RIV year

2013

Released

01.10.2012

Publisher

SPANDIDOS PUBL LTD, POB 18179, ATHENS, 116 10, GREECE

Location

Atény, Řecko

ISBN

1792-1082

Periodical

Oncology Letters

Volume

4

Number

4

State

Hellenic Republic

Pages from

1247

Pages to

1253

Pages count

7

BibTex

@article{BUT95487,
  author="Ondřej {Zítka} and Sylvie {Skaličková} and Jaromír {Gumulec} and Michal {Masařík} and Vojtěch {Adam} and Jaromír {Hubálek} and Libuše {Trnková} and René {Kizek}",
  title="Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients",
  journal="Oncology Letters",
  year="2012",
  volume="4",
  number="4",
  pages="1247--1253",
  doi="10.3892/ol.2012.931",
  issn="1792-1074"
}