Publication result detail

Mammalian metallothioneins: properties and functions

BABULA, P.; MASAŘÍK, M.; ADAM, V.; ECKSCHLAGER, T.; STIBOROVÁ, M.; TRNKOVÁ, L.; ŠKUTKOVÁ, H.; PROVAZNÍK, I.; HUBÁLEK, J.; KIZEK, R.

Original Title

Mammalian metallothioneins: properties and functions

English Title

Mammalian metallothioneins: properties and functions

Type

WoS Article

Original Abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their afinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective efects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc( II ) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a ossible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

English abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their afinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective efects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc( II ) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a ossible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

Keywords

metallothionein, cell proliferation, free radicals

Key words in English

metallothionein, cell proliferation, free radicals

Authors

BABULA, P.; MASAŘÍK, M.; ADAM, V.; ECKSCHLAGER, T.; STIBOROVÁ, M.; TRNKOVÁ, L.; ŠKUTKOVÁ, H.; PROVAZNÍK, I.; HUBÁLEK, J.; KIZEK, R.

RIV year

2013

Released

01.08.2012

Publisher

Royal Society of Chemistry

Location

UK

ISBN

1756-5901

Periodical

Metallomics

Volume

4

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

739

Pages to

750

Pages count

12

Full text in the Digital Library

http://hdl.handle.net/

BibTex

@article{BUT93281,
  author="Petr {Babula} and Michal {Masařík} and Vojtěch {Adam} and Tomáš {Eckschlager} and Marie {Stiborová} and Libuše {Trnková} and Helena {Vítková} and Valentýna {Provazník} and Jaromír {Hubálek} and René {Kizek}",
  title="Mammalian metallothioneins: properties and functions",
  journal="Metallomics",
  year="2012",
  volume="4",
  number="1",
  pages="739--750",
  doi="10.1039/c2mt20081c",
  issn="1756-5901"
}