Publication result detail

Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia

KAŠPÁREK, T.; PŘIKRYL, R.; MIKL, M.; SCHWARZ, D.; ČEŠKOVÁ, E.; KRUPA, P.

Original Title

Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia

English Title

Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia

Type

Peer-reviewed article not indexed in WoS or Scopus

Original Abstract

Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.

English abstract

Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.

Keywords

first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia

Key words in English

first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia

Authors

KAŠPÁREK, T.; PŘIKRYL, R.; MIKL, M.; SCHWARZ, D.; ČEŠKOVÁ, E.; KRUPA, P.

Released

01.01.2007

Publisher

Elsevier

ISBN

0278-5846

Periodical

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Volume

2007

Number

31

State

United Kingdom of Great Britain and Northern Ireland

Pages from

151

Pages to

157

Pages count

7

BibTex

@article{BUT43824,
  author="Tomáš {Kašpárek} and Radovan {Přikryl} and Michal {Mikl} and Daniel {Schwarz} and Eva {Češková} and Petr {Krupa}",
  title="Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia",
  journal="PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY",
  year="2007",
  volume="2007",
  number="31",
  pages="151--157",
  issn="0278-5846"
}