Publication result detail

MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS

HÚSKA, D.; KYNCLOVÁ, H.; HUBÁLEK, J.; BABULA, P.; ECKSCHLAGER, T.; STIBOROVÁ, M.; KIZEK, R.

Original Title

MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS

English Title

MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS

Type

Paper in proceedings (conference paper)

Original Abstract

Cancer is presently one of the most studied lifestyle disease. Its treatment is among others based on chemotherapy. One of the drugs used in chemotherapy is doxorubicin, which interacts with DNA and inhibits division of tumour cells. For better usage of this compound as drug, it is necessary to know its interactions with DNA. In work, interactions between doxorubicin and DNA were monitored using electrochemical methods. In addition, intarcalation of doxorubicin into DNA isolated from resistant as well as sentisive tumour cells was monitored and mutual correlation was searched.

English abstract

Cancer is presently one of the most studied lifestyle disease. Its treatment is among others based on chemotherapy. One of the drugs used in chemotherapy is doxorubicin, which interacts with DNA and inhibits division of tumour cells. For better usage of this compound as drug, it is necessary to know its interactions with DNA. In work, interactions between doxorubicin and DNA were monitored using electrochemical methods. In addition, intarcalation of doxorubicin into DNA isolated from resistant as well as sentisive tumour cells was monitored and mutual correlation was searched.

Keywords

doxorubicin, DNA, tumour cells

Key words in English

doxorubicin, DNA, tumour cells

Authors

HÚSKA, D.; KYNCLOVÁ, H.; HUBÁLEK, J.; BABULA, P.; ECKSCHLAGER, T.; STIBOROVÁ, M.; KIZEK, R.

RIV year

2011

Released

23.06.2010

Publisher

Mendelová univerzita v Brně

Location

Brno

ISBN

978-80-7375-396-2

Book

X. Pracovní setkání fyzikálních chemiků a elektrochemiků

Pages from

96

Pages to

98

Pages count

3

BibTex

@inproceedings{BUT35163,
  author="Dalibor {Húska} and Hana {Kynclová} and Jaromír {Hubálek} and Petr {Babula} and Tomáš {Eckschlager} and Marie {Stiborová} and René {Kizek}",
  title="MONITORING OF DNA-DOXORUBICIN INTERACTIONS BY ELECTROCHEMICAL METHODS",
  booktitle="X. Pracovní setkání fyzikálních chemiků a elektrochemiků",
  year="2010",
  number="1",
  pages="96--98",
  publisher="Mendelová univerzita v Brně",
  address="Brno",
  isbn="978-80-7375-396-2"
}