Publication result detail

Mn(III)-porphyrins in battle against neurodegenerative and cancer diseases

ŠOLTÉS, L.; ARNHOLD, J.; RAPTA, P.; ŠEDIVÝ, M.; NEUGEBAUER, P.; HROUZKOVÁ, S.; SZARKA, A.; MACH, M.; VALACHOVÁ, K.

Original Title

Mn(III)-porphyrins in battle against neurodegenerative and cancer diseases

English Title

Mn(III)-porphyrins in battle against neurodegenerative and cancer diseases

Type

Scopus Article

Original Abstract

Manganese(III)-porphyrins − Mn(III)P−exhibit remarkable redox activity, influencing oxidative and antioxidative processes in biological systems. In this study, we explore the dual roles of Mn(III)-2-TE-PyP5+ and Mn(III)-4-TE-PyP5+ in modulating hyaluronan degradation, a key factor in both neuroprotection and cancer therapy. While Mn(III)-2-TE-PyP5+ enhances oxidative degradation of high-molecular weight hyaluronan, facilitating immune recognition of cancer cells, its structural isomer Mn(III)-4-TE-PyP5+ acts as a potent antioxidant, safeguarding neuronal integrity against oxidative stress. Employing rotational viscometry, oximetry, electron paramagnetic resonance (EPR), and gas chromatography-mass spectrometry (GC-MS), we delineate the mechanisms underlying the redox transformations of Mn(III)P-derivatives and their impact on glycocalyx integrity. Our findings provide new insights into the selective therapeutic applications of Mn(III)P-derivatives, offering promising strategies for targeted cancer treatment and neurodegenerative disease prevention.

English abstract

Manganese(III)-porphyrins − Mn(III)P−exhibit remarkable redox activity, influencing oxidative and antioxidative processes in biological systems. In this study, we explore the dual roles of Mn(III)-2-TE-PyP5+ and Mn(III)-4-TE-PyP5+ in modulating hyaluronan degradation, a key factor in both neuroprotection and cancer therapy. While Mn(III)-2-TE-PyP5+ enhances oxidative degradation of high-molecular weight hyaluronan, facilitating immune recognition of cancer cells, its structural isomer Mn(III)-4-TE-PyP5+ acts as a potent antioxidant, safeguarding neuronal integrity against oxidative stress. Employing rotational viscometry, oximetry, electron paramagnetic resonance (EPR), and gas chromatography-mass spectrometry (GC-MS), we delineate the mechanisms underlying the redox transformations of Mn(III)P-derivatives and their impact on glycocalyx integrity. Our findings provide new insights into the selective therapeutic applications of Mn(III)P-derivatives, offering promising strategies for targeted cancer treatment and neurodegenerative disease prevention.

Keywords

Glycocalyx; Hyaluronan; Mn(III)-porphyrins; Neuroprotection; Rotational viscometry; Targeted cancer treatment

Key words in English

Glycocalyx; Hyaluronan; Mn(III)-porphyrins; Neuroprotection; Rotational viscometry; Targeted cancer treatment

Authors

ŠOLTÉS, L.; ARNHOLD, J.; RAPTA, P.; ŠEDIVÝ, M.; NEUGEBAUER, P.; HROUZKOVÁ, S.; SZARKA, A.; MACH, M.; VALACHOVÁ, K.

Released

01.10.2025

Publisher

Elsevier Masson s.r.l.

ISBN

0753-3322

Periodical

BIOMEDICINE & PHARMACOTHERAPY

Volume

191

Number

118488

State

French Republic

Pages count

12

URL

https://www.sciencedirect.com/science/article/pii/S0753332225006821

BibTex

@article{BUT198693,
  author="Ladislav {Šoltés} and Jürgen {Arnhold} and Peter {Rapta} and Matúš {Šedivý} and Petr {Neugebauer} and Svetlana {Hrouzková} and Agneša {Szarka} and Mojmír {Mach} and Katarína {Valachová}",
  title="Mn(III)-porphyrins in battle against neurodegenerative and cancer diseases",
  journal="BIOMEDICINE & PHARMACOTHERAPY",
  year="2025",
  volume="191",
  number="118488",
  pages="12",
  doi="10.1016/j.biopha.2025.118488",
  issn="0753-3322",
  url="https://www.sciencedirect.com/science/article/pii/S0753332225006821"
}