Publication result detail

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

MONTUFAR JIMENEZ, E.

Original Title

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

English Title

Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility

Type

WoS Article

Original Abstract

This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.

English abstract

This review focuses on the bone response to biodegradable metals used in temporary osteosynthesis devices. These implants are designed to degrade in vivo, fully dissolving after stabilizing fractures, osteotomies, and ligament fixations, thus eliminating the need for a second surgery. The review delves into the interactions between biodegradable metallic implants and bone tissue, emphasizing the bidirectional nature of this process. It covers the families of biodegradable metals and their degradation mechanisms, with particular attention paid to the time-dependence of the foreign body reaction and the local sterile inflammation response. Additionally, the review discusses current in vitro methods for evaluating biological safety, osteogenic properties, and inflammatory responses. The limitations of traditional cell culture models in replicating the in vivo bone environment are discussed, along with recent advancements in the field. The review concludes by proposing strategies to control the degradation of biodegradable metals and more accurately replicate bone tissue, which could potentially enable more precise in vitro degradation and biological characterization, reducing reliance on in vivo experiments.

Keywords

TUNGSTEN COILS; MECHANICAL-PROPERTIES; DEGRADABLE MAGNESIUM; HUMAN OSTEOBLASTS; VIVO; BIOCOMPATIBILITY; SCAFFOLDS; CELLS; ALLOYS; IRON

Key words in English

TUNGSTEN COILS; MECHANICAL-PROPERTIES; DEGRADABLE MAGNESIUM; HUMAN OSTEOBLASTS; VIVO; BIOCOMPATIBILITY; SCAFFOLDS; CELLS; ALLOYS; IRON

Authors

MONTUFAR JIMENEZ, E.

Released

01.06.2025

Publisher

SPRINGER

Location

NEW YORK

ISBN

1543-1851

Periodical

JOM

Volume

77

Number

6

State

United States of America

Pages from

4473

Pages to

4492

Pages count

20

URL

https://link.springer.com/article/10.1007/s11837-025-07353-8

BibTex

@article{BUT197800,
  author="Edgar Benjamin {Montufar Jimenez}",
  title="Bone Response to Biodegradable Metals and In Vitro Evaluation of the Cytocompatibility",
  journal="JOM",
  year="2025",
  volume="77",
  number="6",
  pages="4473--4492",
  doi="10.1007/s11837-025-07353-8",
  issn="1047-4838",
  url="https://link.springer.com/article/10.1007/s11837-025-07353-8"
}