Publication result detail

Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering

HAVLÍKOVÁ, T.; PAPEŽ, N.; FOHLEROVÁ, Z.; KASPAR, P.; DALLAEV, R.; ČÁSTKOVÁ, K.; ŢĂLU, Ş.

Original Title

Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering

English Title

Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering

Type

WoS Article

Original Abstract

This study focused on the development of a suitable synthetic polymer scaffold for bone tissue engineering applications within the biomedical field. The investigation centered on electrospun polyvinylidene fluoride (PVDF) nanofibers, examining their intrinsic properties and biocompatibility with the human osteosarcoma cell line Saos-2. The influence of oxygen, argon, or combined plasma treatment on the scaffold’s characteristics was explored. A comprehensive design strategy is outlined for the fabrication of a suitable PVDF scaffold, encompassing the optimization of electrospinning parameters with rotating collector and plasma etching conditions to facilitate a subsequent osteoblast cell culture. The proposed methodology involves the fabrication of the PVDF tissue scaffold, followed by a rigorous series of fundamental analyses encompassing the structural integrity, chemical composition, wettability, crystalline phase content, and cell adhesion properties.

English abstract

This study focused on the development of a suitable synthetic polymer scaffold for bone tissue engineering applications within the biomedical field. The investigation centered on electrospun polyvinylidene fluoride (PVDF) nanofibers, examining their intrinsic properties and biocompatibility with the human osteosarcoma cell line Saos-2. The influence of oxygen, argon, or combined plasma treatment on the scaffold’s characteristics was explored. A comprehensive design strategy is outlined for the fabrication of a suitable PVDF scaffold, encompassing the optimization of electrospinning parameters with rotating collector and plasma etching conditions to facilitate a subsequent osteoblast cell culture. The proposed methodology involves the fabrication of the PVDF tissue scaffold, followed by a rigorous series of fundamental analyses encompassing the structural integrity, chemical composition, wettability, crystalline phase content, and cell adhesion properties.

Keywords

biocompatibility; bone tissue engineering; bone regeneration; cell–substrate interactions; electrospinning; nanofiber fabrication; osteoblasts; piezoelectric polymer; plasma treatment; polyvinylidene fluoride; scaffold

Key words in English

biocompatibility; bone tissue engineering; bone regeneration; cell–substrate interactions; electrospinning; nanofiber fabrication; osteoblasts; piezoelectric polymer; plasma treatment; polyvinylidene fluoride; scaffold

Authors

HAVLÍKOVÁ, T.; PAPEŽ, N.; FOHLEROVÁ, Z.; KASPAR, P.; DALLAEV, R.; ČÁSTKOVÁ, K.; ŢĂLU, Ş.

Released

25.01.2025

Publisher

MDPI

Location

BASEL

ISBN

2073-4360

Periodical

Polymers

Volume

17

Number

3

State

Swiss Confederation

Pages count

23

URL

https://www.mdpi.com/2073-4360/17/3/330

Full text in the Digital Library

http://hdl.handle.net/11012/255386

BibTex

@article{BUT196640,
  author="Tereza {Havlíková} and Nikola {Papež} and Zdenka {Fohlerová} and Pavel {Kaspar} and Rashid {Dallaev} and Klára {Částková} and Ştefan {Ţălu}",
  title="Adaptability of Electrospun PVDF Nanofibers in Bone Tissue Engineering",
  journal="Polymers",
  year="2025",
  volume="17",
  number="3",
  pages="23",
  doi="10.3390/polym17030330",
  url="https://www.mdpi.com/2073-4360/17/3/330"
}

Documents

polymers-17-00330-v2