Publication result detail

Microfluidics chips fabrication techniques comparison

LIU, X.; SUN, A.; BRODSKÝ, J.; GABLECH, I.; LEDNICKÝ, T; VOPAŘILOVÁ, P.; ZÍTKA, O.; ZENG, W.; NEUŽIL, P.

Original Title

Microfluidics chips fabrication techniques comparison

English Title

Microfluidics chips fabrication techniques comparison

Type

WoS Article

Original Abstract

This study investigates various microfluidic chip fabrication techniques, highlighting their applicability and limitations in the context of urgent diagnostic needs showcased by the COVID-19 pandemic. Through a detailed examination of methods such as computer numerical control milling of a polymethyl methacrylate, soft lithography for polydimethylsiloxane-based devices, xurography for glass-glass chips, and micromachining-based silicon-glass chips, we analyze each technique's strengths and trade-offs. Hence, we discuss the fabrication complexity and chip thermal properties, such as heating and cooling rates, which are essential features of chip utilization for a polymerase chain reaction. Our comparative analysis reveals critical insights into material challenges, design flexibility, and cost-efficiency, aiming to guide the development of robust and reliable microfluidic devices for healthcare and research. This work underscores the importance of selecting appropriate fabrication methods to optimize device functionality, durability, and production efficiency.

English abstract

This study investigates various microfluidic chip fabrication techniques, highlighting their applicability and limitations in the context of urgent diagnostic needs showcased by the COVID-19 pandemic. Through a detailed examination of methods such as computer numerical control milling of a polymethyl methacrylate, soft lithography for polydimethylsiloxane-based devices, xurography for glass-glass chips, and micromachining-based silicon-glass chips, we analyze each technique's strengths and trade-offs. Hence, we discuss the fabrication complexity and chip thermal properties, such as heating and cooling rates, which are essential features of chip utilization for a polymerase chain reaction. Our comparative analysis reveals critical insights into material challenges, design flexibility, and cost-efficiency, aiming to guide the development of robust and reliable microfluidic devices for healthcare and research. This work underscores the importance of selecting appropriate fabrication methods to optimize device functionality, durability, and production efficiency.

Keywords

Microfluidics; Fabrication techniques; Thermal properties

Key words in English

Microfluidics; Fabrication techniques; Thermal properties

Authors

LIU, X.; SUN, A.; BRODSKÝ, J.; GABLECH, I.; LEDNICKÝ, T; VOPAŘILOVÁ, P.; ZÍTKA, O.; ZENG, W.; NEUŽIL, P.

RIV year

2025

Released

20.11.2024

Publisher

NATURE PORTFOLIO

Location

ENGLAND

ISBN

2045-2322

Periodical

Scientific Reports

Volume

14

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

13

Pages count

13

URL

https://www.nature.com/articles/s41598-024-80332-2

Full text in the Digital Library

http://hdl.handle.net/11012/250052

BibTex

@article{BUT193659,
  author="Xiaocheng {Liu} and Antao {Sun} and Jan {Brodský} and Imrich {Gablech} and Tomáš {Lednický} and Petra {Vopařilová} and Ondřej {Zítka} and Wen {Zeng} and Pavel {Neužil}",
  title="Microfluidics chips fabrication techniques comparison",
  journal="Scientific Reports",
  year="2024",
  volume="14",
  number="1",
  pages="1--13",
  doi="10.1038/s41598-024-80332-2",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-024-80332-2"
}

Documents

s41598-024-80332-2