Micro/Nanorobots for Advanced Light-Based Biosensing and Imaging

Micro/Nanorobots for Advanced Light-Based Biosensing and Imaging

WoS Article

Sensing and imaging of biomolecules are crucial to disease diagnosis, prognosis, and therapy where optical techniques have essential utility. Untethered and remotely controlled micro/nanorobots have shown promising sensing and imaging capabilities, especially in complex biological environments. In this review, how micro/nanorobots are used for optical biosensing and imaging while highlighting the significant developments in the field is discussed. Starting is done by exploring colorimetric biosensing methods enabled by micro/nanorobots. Significant advancements in surface-enhanced Raman spectroscopy-integrated micro/nanorobots are reviewed. Further, state-of-the-art optical bio-imaging applications by micro/nanorobots at in vitro intracellular level are highlighted. Novel in vivo bio-imaging assisted by optical micro/nanorobot sensors is examined. Furthermore, innovations in micro/nanorobots are assessed where motion augmentation is used as a detection mechanism, with applications in point-of-care molecular diagnostics. Finally, the challenges associated with micro/nanorobots-assisted advanced optical biosensing and imaging while discussing insights about potential research directions for this rapidly progressing field are summarized. This review highlights advances in micro/nanorobots-enabled light-based biosensing and imaging. Untethered and remotely controlled micro/nanorobots enable precision biosensing using colorimetric and surface-enhanced Raman spectroscopy methods. They also provide cutting-edge in vitro intracellular and in vivo bioimaging in complex biological environments and organs. Furthermore, micro/nanorobots facilitate the development of point-of-care optical biosensors, enhancing disease diagnosis and prognosis capabilities in medical applications. image

Sensing and imaging of biomolecules are crucial to disease diagnosis, prognosis, and therapy where optical techniques have essential utility. Untethered and remotely controlled micro/nanorobots have shown promising sensing and imaging capabilities, especially in complex biological environments. In this review, how micro/nanorobots are used for optical biosensing and imaging while highlighting the significant developments in the field is discussed. Starting is done by exploring colorimetric biosensing methods enabled by micro/nanorobots. Significant advancements in surface-enhanced Raman spectroscopy-integrated micro/nanorobots are reviewed. Further, state-of-the-art optical bio-imaging applications by micro/nanorobots at in vitro intracellular level are highlighted. Novel in vivo bio-imaging assisted by optical micro/nanorobot sensors is examined. Furthermore, innovations in micro/nanorobots are assessed where motion augmentation is used as a detection mechanism, with applications in point-of-care molecular diagnostics. Finally, the challenges associated with micro/nanorobots-assisted advanced optical biosensing and imaging while discussing insights about potential research directions for this rapidly progressing field are summarized. This review highlights advances in micro/nanorobots-enabled light-based biosensing and imaging. Untethered and remotely controlled micro/nanorobots enable precision biosensing using colorimetric and surface-enhanced Raman spectroscopy methods. They also provide cutting-edge in vitro intracellular and in vivo bioimaging in complex biological environments and organs. Furthermore, micro/nanorobots facilitate the development of point-of-care optical biosensors, enhancing disease diagnosis and prognosis capabilities in medical applications. image

biosensing; intracellular; in vivo imaging; micro/nanorobots; optical; SERS

biosensing; intracellular; in vivo imaging; micro/nanorobots; optical; SERS

NEETTIYATH, A.; PUMERA, M.

01.02.2025

WILEY-V C H VERLAG GMBH

WEINHEIM

1616-3028

ADVANCED FUNCTIONAL MATERIALS

35

8

Federal Republic of Germany

19

https://onlinelibrary.wiley.com/doi/10.1002/adfm.202415875